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ePoster
RAB18 REGULATES ADULT NEUROGENESIS AND INNATE BEHAVIOR
Tsu-Wei Wangand 3 co-authors
Natuonal Taiwan Normal University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-221
Presentation
Date TBA
Board: PS01-07AM-221
Event Information
Poster Board
PS01-07AM-221
Poster
View posterAbstract
Neurogenesis persists in the olfactory bulb (OB) and hippocampus throughout life in the mammalian brain. Neural stem cells (NSCs) in the postnatal subventricular zone (SVZ) of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) maintain adult neurogenesis in the OB and DG, respectively. Adult neurogenesis is required for innate olfactory behaviors and spatial learning and memory. Rab18, a Ras-like small GTPase, is essential for the development of the mammalian nervous system. Whether Rab18 also regulates adult neurogenesis and related behaviors remains elusive. Here, we found that adult neurogenesis in the OB and DG was decreased in Rab18 null mice. Furthermore, odor discrimination and spatial learning and memory were defective in Rab18 null mice. Our data suggest that Rab18 is required for adult neurogenesis and OB- and DG-dependent behaviors.
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