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REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) MODULATES HIPPOCAMPAL ASTROCYTES, GABA-GLUTAMATE SYSTEM, AND BEHAVIOR IN A POSTNATAL MK-801 MODEL OF SCHIZOPHRENIA: A SEX-DEPENDENT STUDY.
David Meneses San Juanand 1 co-author
Ramon de la Fuente Muñíz National Institute of Psychiatry
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-500
Presentation
Date TBA
Board: PS01-07AM-500
Event Information
Poster Board
PS01-07AM-500
Poster
View posterAbstract
Schizophrenia (SZ) involves glutamatergic/GABAergic alterations. Postnatal MK-801, an NMDA antagonist, models negative symptoms (social isolation, anhedonia, hypolocomotion). Astrocytes, implicated in SZ, regulate GABA-glutamate transmission. Repetitive Transcranial Magnetic Stimulation (rTMS) may have therapeutic potential. We hypothesized rTMS reverses behaviors by modulating hippocampal astrocytes and the GABA-glutamate system. Male/female FVB/N mice were divided into: NaCl+Sham, MK-801+Sham, NaCl+rTMS, MK-801+rTMS. MK-801 (0.1 mg/kg) was administered neonatally (P7-14). Behaviors were assessed in adolescence (P51-54) and adulthood (P103-105). rTMS (10 Hz) was applied in adulthood (P110-140). Hippocampal astrocyte (GFAP) and interneuron (parvalbumin) density, and GABA/glutamate levels were analyzed. Neonatal MK-801 induced anhedonia, hypolocomotion, and social isolation, effects more prominent in males from adolescence. It reduced astrocyte density in the hilus (both sexes) and interneurons (males only), while increasing extracellular glutamate and intracellular GABA. rTMS reversed MK-801-induced hypolocomotion and social isolation in males, restored astrocyte density, increased interneuron density, and partially (males) or fully (females) reversed glutamate/GABA alterations. In conclusion, 10 Hz rTMS exerts a therapeutic effect in an SZ model, possibly mediated by astrocytes and the GABA-glutamate system, with sex-dependent influences.
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