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REUSABLE REDUCED-WEIGHT <EM>NEUROPIXELS</EM> IMPLANT FOR STABLE CHRONIC RECORDINGS IN SMALL ADULT MICE
Mengzhen Zhangand 3 co-authors
University of Edinburgh
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-392
Presentation
Date TBA
Board: PS01-07AM-392
Event Information
Poster Board
PS01-07AM-392
Poster
View posterAbstract
Conducting chronic, stable, large-scale in vivo electrophysiological recordings remains a challenge in systems neuroscience, especially for female mice which are usually smaller in size and lighter in weight. To improve inclusivity of female mice in longitudinal neurobehavioural studies using Neuropixels probes, the chronic implant should not only allow long-term stable recordings and be reusable after explantation, but also the weight needs to be further reduced. Here, we present a lighter-weight version of Apollo Implant that inherits all advantages from the original design, and remains stable for weeks despite 20% reduction in weight. We tested this new implant in head-restricted female mice during passive visual stimulation viewing and active navigation in virtual reality. In both conditions, we acquired high-quality units across multiple brain regions for at least three weeks, and the total number stablises to around 100 after one week. Our lighter-weight version of Apollo Implant improves inclusivity and flexibility in longitudinal experiments using Neuropixels without impairing data quality.
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