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ROLE OF MYELINATION IN THE MATURATION OF SPATIAL ORIENTATION CIRCUIT
Rawan Issawiand 7 co-authors
Paris Brain Institute- Sorbonne University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-466
Presentation
Date TBA
Board: PS02-07PM-466
Event Information
Poster Board
PS02-07PM-466
Poster
View posterAbstract
Myelin contributes to the efficient propagation of action potential along axons, which is necessary for animals to interact with the environment with timeless and precision. Spatial learning is an essential cognitive function that involves coordination between different cortical and subcortical structures to integrate spatial and visual information. Maturation of spatially modulated neurons and myelination of their axons occur at very similar times during development. We have hypothesized that myelin could contribute to regulating the maturation of spatial orientation circuit. We manipulated oligodendrogenesis and prevented the progression of myelination by conditionally inducing Mrf deletion in OPCs after first steps of myelination in young mice. A strong reduction in oligodendrogenesis and myelination was observed in the hippocampo-thalamic-retrosplenial regions of the spatial orientation circuit in the Mrf-iKO mice. The spatial orientation abilities of control and Mrf-iKO mice in adolescence and early adulthood were tested in the Morris Water Maze. We observed no alteration in the swimming speed of Mrf-iKO mice. Analysis of trajectories, cumulative distance and time spent in the target quadrant to reach a hidden platform revealed an alteration in orientation ability of young adult Mrf-iKO mice compared to control mice. Cellular mechanisms were studied by measuring changes in the intrinsic excitability of neurons and impact on synaptic connectivity. These results should help to understand how spatial navigation develops and how myelin contributes to the maturation of spatial orientation activities.
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