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SHARED AND SUBTYPE-SPECIFIC SERUM PROTEOMIC SIGNATURES IN SMALL CELL AND NON-SMALL CELL LUNG CANCER
Yaren Aydoganand 6 co-authors
Regenerative and Restorative Medical Research Center (REMER), Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-532
Presentation
Date TBA
Board: PS05-09AM-532
Event Information
Poster Board
PS05-09AM-532
Poster
View posterAbstract
Lung cancer is a highly lethal disease caused by genetic alterations in the bronchial epithelium and accounts for approximately 18% of cancer-related deaths worldwide. It is classified into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). The aim of this study was to identify serum proteins that are commonly or differentially altered between lung cancer subtypes and to evaluate their potential as circulating biomarkers. Serum samples from healthy controls, SCL, and NSCLC patients were subjected to depletion of most abundant proteins to improve proteome coverage, followed by liquid chromatography tandem mass spectrometry based proteomic analysis. The analysis showed that 63 proteins were significantly altered in both SCLC and NSCLC compared with controls, while 20 proteins in SCLC and 21 proteins in NSCLC showed subtype specific changes. Proteins commonly altered in both subtypes were associated with acute phase response, lipid metabolism and systemic inflammatory regulation, including albumin, haptoglobin, apolipoproteins A2 and A4, transthyretin, ALPHA 1 acid glycoproteins 1 and 2, complement components and glycolytic enzymes, indicating a shared cancer associated systemic response between SCLC and NSCLC. In contrast, SCLC displayed a distinct serum proteomic network characterized by enhanced innate immune and complement activation involving C1qa, C3, apolipoprotein C1 and cathepsin D. A direct interaction between serum amyloid A1 and serum amyloid A2 was uniquely observed in SCLC. In conclusion, while SCLC and NSCLC share a common systemic proteomic signature, SCLC is distinguished by a pronounced innate immune complement and acute phase axis, highlighting potential subtype specific circulating biomarkers.
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