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THE TROPHIC PHYSIOLOGICAL ROLE OF S100B PROTEIN
Fabrizio Michettiand 2 co-authors
Genes
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-192
Presentation
Date TBA
Board: PS01-07AM-192
Event Information
Poster Board
PS01-07AM-192
Poster
View posterAbstract
The S100B protein is highly concentrated in astrocytes in the nervous system. It is regarded as a faceted Jekyll/Hyde protein displaying a trophic role at low physiological concentration and a toxic role at high concentration. The toxic aspect (Hyde side) of the protein has been intensively studied, so that high S100B levels in biological fluids at present constitute a reliable biomarker of active injury, and the protein is also regarded as an active factor and, as a consequence, as a putative therapeutic target of brain injury (1). In contrast, trophic aspects of S100B (Jekyll side) have been disregarded, although they deserve attention, being the physiological role of the protein. First, S100B is a natural constituent of human milk, reasonably participating of trophic messages from the mother to the newborn. Recently S100B has also been shown to be a natural constituent of vegetables commonly used in a healthy diet , and it has also been shown to affect the biodiversity of gut microbiota (2), so that its trophic role in aliments may be transmitted to the whole body, including brain, through the gut-brain axis.
1.Michetti F et al Int J Mol Sci. 2023;24:9605. doi: 10.3390/ijms24119605
2.Michetti F, Romano Spica V. Nutrients. 2025 ;17:881. doi: 10.3390/nu17050881
1.Michetti F et al Int J Mol Sci. 2023;24:9605. doi: 10.3390/ijms24119605
2.Michetti F, Romano Spica V. Nutrients. 2025 ;17:881. doi: 10.3390/nu17050881
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