Skip to contentSkip to filters
World Wide
Sign in

We use cookies for analytics.

Exploratory research grant

NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

National Institutes of Health

View call page (opens in a new tab)
  • Up to $275,000
  • Worldwide
  • Institution applies
  • Medicine, Biology and
Related content

About

NIH PA-25-304 supports exploratory biomedical, behavioral and clinical research at an early conceptual stage, including risky approaches, new methods and models. Clinical trials are not permitted. Projects must fit a participating NIH institute or center. The next new-application deadline is October 16, 2026 at 5 p.m. in the applicant organization’s local time; the next resubmission deadline is November 16. Direct costs are limited to USD 275,000 over two years and USD 200,000 in any one year. Apply through ASSIST, Grants.gov Workspace or an institutional system; organizational registrations and PI eRA Commons/ORCID records must be complete. Foreign subawards or subcontracts are prohibited under this notice, even though foreign organizations may apply.

Topics

Eligibility

Covers: Up to USD 275,000 in direct costs over at most two years, with no more than USD 200,000 in one year. No cost sharing required. Clinical trials and foreign subawards/subcontracts are excluded.

Domestic and foreign applicant organizations are eligible. Monetary foreign subawards/subcontracts are not permitted under this notice; funded international collaborations require a designated NOFO. Unfunded collaborations, foreign components, foreign consultants and procurement remain subject to NIH rules.

grants.nih.gov

Eligible domestic and foreign organizations include higher education institutions, nonprofits, businesses and the government/community entity categories listed in the notice. PIs must have the skills, resources and knowledge to perform the work and apply with an eligible organization.

Source: grants.nih.gov