Physiology ePosters

Animals are dynamical systems possessing a wide range of capabilities mediated by interactions between their constitutive cells. The brain, central integrator and coordinator of bodily output, solves problems in the context of bodily needs, driven by external environmental signals and internal bodily signals. While…

The evolution of the Na$^+$/K$^+$-ATPase in ancestral methanogenic archaea also lay the foundation for the energetics of energy-intensive signaling tissues like the metazoan nervous systems billions of years later [1]. The electrogenic property of this pump, which leads to activity-dependent feedback [2], seems a…

Aims. Acute consumption of sweeteners has become increasingly common in modern diets. However, emerging research suggests that the impact of sweeteners on the hypothalamus, involved in regulating food intake [CA1] and metabolism, may be deleterious. Several studies have raised concerns about their potential effects on…

Respiratory dysfunction, particularly central apnea, accompanied by cardiac abnormalities are proposed to be the underlying causes of Sudden Unexpected Death in Epilepsy (SUDEP). Apnea in SUDEP is characterised by prologued hypercapnia with severe hypoventilation. We propose that this implies an impairment at the…

PKA, influenced by retrograde signalling from muscle contraction, enhances neurotransmission at the neuromuscular junction (NMJ). This occurs through the phosphorylation of key molecules in synaptic vesicle exocytosis, SNAP-25 and Synapsin-1. The BDNF/TrkB pathway, augmented by muscle contraction, is a known regulator…