TWiV 1361: Ancient Viral Sword and Shield

Vincent Racaniello, Alan Dove and Brianne Barker discuss a newly identified mechanism for RNA-guided DNA recognition and genetic control that may predate CRISPR pathways. They also examine research proposing that features of Alzheimer’s disease neuropathology could have originated as a host response to infection in the brain, including evidence concerning phosphorylated tau and herpesvirus activity. The episode connects ancient molecular recognition mechanisms with questions about antiviral defence.