TWiV 1357: Furin, Naturally with Paul Bieinasz

Paul Bieniasz joins Vincent Racaniello, Alan Dove and Kathy Spindler to discuss his laboratory’s research on coronavirus genetic variation. The conversation examines how the NSP15 nuclease cuts viral RNA into short pieces that can be reinserted elsewhere, producing insertion mutations and new furin-cleavage sites at the spike S1/S2 boundary. The episode links the underlying preprint and includes listener correspondence and weekly selections.