Guidelines concerning the potentially harmful effects of scientific studies have historically focused on minimizing risk for participants. However, studies can also indirectly inflict harm on individuals and social groups through how they are designed, reported, and disseminated. As evidenced by recent criticisms and retractions of high-profile studies dealing with a wide variety of social issues, there is a scarcity of resources and guidance on how one can conduct research in a socially responsible manner. As such, even motivated researchers might publish work that has negative social impacts due to a lack of awareness. To address this, we proposed 10 recommendations (“simple rules”) for researchers who wish to conduct more socially responsible science. These recommendations cover major considerations throughout the life cycle of a study from inception to dissemination. They are not aimed to be a prescriptive list or a deterministic code of conduct. Rather, they are meant to help motivated scientists to reflect on their social responsibility as researchers and actively engage with the potential social impact of their research.