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Dr.
Harvard University
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Schedule
Sunday, March 6, 2022
4:00 PM America/Los_Angeles
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Recording provided by the organiser.
Domain
Physics of LifeHost
SLAAM by UC Merced
Duration
70 minutes
Self-organization is a universal concept spanning numerous disciplines including mathematics, physics and biology. Chromosomes are self-organizing polymers that fold into orderly, hierarchical and yet dynamic structures. In the past decade, advances in experimental biology have provided a means to reveal information about chromosome connectivity, allowing us to directly use this information from experiments to generate 3D models of individual genes, chromosomes and even genomes. In this talk I will present a novel data-driven modeling approach and discuss a number of possibilities that this method holds. I will discuss a detailed study of the time-evolution of X chromosome inactivation, highlighting both global and local properties of chromosomes that result in topology-driven dynamical arrest and present and characterize a novel type of motion we discovered in knots that may have applications to nanoscale materials and machines.
Anna Lappala
Dr.
Harvard University
Contact & Resources
open source
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