Seminar · Biophysics
4D Chromosome Organization: Combining Polymer Physics, Knot Theory and High Performance Computing
Anna Lappala · Harvard University
Mon, Mar 7, 2022 · 00:00 UTC
Self-organization is a universal concept spanning numerous disciplines including mathematics, physics and biology. Chromosomes are self-organizing polymers that fold into orderly, hierarchical and yet dynamic structures. In the past decade, advances in experimental biology have provided a means to reveal information about chromosome connectivity, allowing us to directly use this information from experiments to generate 3D models of individual genes, chromosomes and even genomes. In this talk I will present a novel data-driven modeling approach and discuss a number of possibilities that this me