Self-organization

…Experience-driven self-organization provides a complementary mechanism for neural circuit development which instead yields conserved features like orientation tuning, but has also mainly been studied in sensory cortices or artificial neural networks (ANNs). Here we pursue a high level perspective on conservation of topographies and feature spaces throughout the cortex using blood oxygen level d

Activity-dependent structural plasticity plays a pivotal role in the self-organization of neuronal networks. Emerging activity continuously feeds back into the growth process, regulating connectivity and activity homeostatically towards an optimal functional dynamic range. Transferred into cell culture, neurons follow the same homeostatic principles. They migrate and regrow neurites to establish synaptic connectivity and spontaneous network activity. Despite of homeostatic regulation, the resulting network structure and activity dynamics exhibit considerable variability across and within studi

Place Cells (PCs), are neurons that exhibit localized firing when an animal enters specific areas within an environment. Despite extensive experimental study revealing their link to cognitive functions, the precise cellular mechanisms underlying the transformation of a hippocampal neuron into a Place Cell remain incompletely understood. In our research, we employed a detailed computational model of a CA1 pyramidal neuron, considering both its morphology and biophysics. We aimed to elucidate how, and under what circumstances, such a neuron could encode a specific location based on the self-orga

Self-organization is a universal concept spanning numerous disciplines including mathematics, physics and biology. Chromosomes are self-organizing polymers that fold into orderly, hierarchical and yet dynamic structures. In the past decade, advances in experimental biology have provided a means to reveal information about chromosome connectivity, allowing us to directly use this information from experiments to generate 3D models of individual genes, chromosomes and even genomes. In this talk I will present a novel data-driven modeling approach and discuss a number of possibilities that this me

…of these micro-swimmers is driving self-organization processes at the origin of o