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Goshen lab, Edmond and Lily Safra Center for Brain Sciences
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Schedule
Wednesday, April 7, 2021
7:35 PM Europe/Berlin
Recording provided by the organiser.
Domain
NeuroscienceHost
WWNeuRise
Duration
35 minutes
How is it that some memories fade in a day while others last forever? The formation of long-lasting (remote) memories depends on the coordinated activity between the hippocampus and frontal cortices, but the timeline of these interactions is debated. Astrocytes, star-shaped glial cells, sense and modify neuronal activity, but their role in remote memory is scarcely explored. We manipulated the activity of hippocampal astrocytes during memory acquisition and discovered it impaired remote, but not recent, memory retrieval. We also revealed a massive recruitment of cortical-projecting hippocampal neurons during memory acquisition, a process that is specifically inhibited by astrocytic manipulation. Finally, we directly inhibited this projection during memory acquisition to prove its necessity for the formation of remote memory. Our findings reveal that the foundation of remote memory can be established during acquisition with projection-specific effect of astrocytes.
Adi Kol
Goshen lab, Edmond and Lily Safra Center for Brain Sciences
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