Remote memory

…cortex (PL) is required for fear memory retrieval across time and is densely interconnected with many subcortical and cortical areas involved in recent and remote memory recall, including the temporal association area (TeA). While the behavioral expression of a memory may remain constant over time, the neural activity mediating memory-guided behavior is dynamic. In PL, different neurons underlie recent and remote memory retrieval and remote memory-encoding neurons have

…related to learning, as well as memory consolidation (DOI: 10.1038/s41583-020-0360-9). Less is known about its role in memory retrieval. In this study, we explored this aspect following training of adult rats over a period of multiple days in an 8-arm radial maze to achieve robust spatial working memory (WM) and reference memory (RM) of the task. We then examined the consequence of patterned electrophysiological activation of the LC on the retrieval of recent (24h after the conclusion of training) or remote

…to identify early alterations in memory formation. Our findings indicate that Aβ1

Acquisition, consolidation, and retrieval of recent and remote memory rely on the coordinated neuronal activity of different brain regions. Inhibitory neurons, or Interneurons (IN), play a critical role in shaping neuronal networks by selectively gating signal flow. Parvalbumin-IN (PV-IN) is one of the predominant interneurons and is known to be involved in memory consolidation and development. However, its role in maintaining memory specificity is still elusive. Here, we perturbed PV-IN activity and found that the activity of PV-IN is needed to maintain recent memory specificity. Interestingl

…The formation of long-lasting (remote) memories depends on the coordinated activity between the hippocampus and frontal cortices, but the timeline of these interactions is debated. Astrocytes, star-shaped glial cells, sense and modify neuronal activity, but their role in remote memory is scarcely explored. We manipulated the activity of hippocampal astrocytes during memory acquisition and discovered it impaired remote, but not recent, memory retrieval. We also revealed a massive recruitment of cortical-projecting hippocampal