Topic: recent memory

Neuromodulation by the locus coeruleus (LC) plays a crucial role in cognitive processes related to learning, as well as memory consolidation (DOI: 10.1038/s41583-020-0360-9). Less is known about its role in memory retrieval. In this study, we explored this aspect following training of adult rats over a period of multiple days in an 8-arm radial maze to achieve robust spatial working memory (WM) and reference memory (RM) of the task. We then examined the consequence of patterned electrophysiological activation of the LC on the retrieval of recent (24h after the conclusion of training) or remote

Acquisition, consolidation, and retrieval of recent and remote memory rely on the coordinated neuronal activity of different brain regions. Inhibitory neurons, or Interneurons (IN), play a critical role in shaping neuronal networks by selectively gating signal flow. Parvalbumin-IN (PV-IN) is one of the predominant interneurons and is known to be involved in memory consolidation and development. However, its role in maintaining memory specificity is still elusive. Here, we perturbed PV-IN activity and found that the activity of PV-IN is needed to maintain recent memory specificity. Interestingl