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Common Developmental Mechanisms Underlie

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Seminar✓ Recording AvailableNeuroscience

Common developmental mechanisms underlie multiple brain disorders linked to corpus callosum dysgenesis. (Simultaneous translation to Spanish)

Linda J. Richards AO, FAA, FAHMS, PhD.

Professor

Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

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Sunday, October 18, 2020

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Sunday, October 18, 2020

6:00 PM America/Montevideo

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Host: IIBCE on Brain Science

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Abstract

The corpus callosum is the largest fibre tract in the brain of placental mammals and connects the two cerebral hemispheres. Corpus callosum dysgenesis is a developmental brain disorder that is commonly genetic and occurs in approximately 1:4000 live births. It is easily diagnosed by MRI or prenatal ultrasound and is found in isolation or together with other brain anomalies, or with other organ system defects in a large number of different congenital syndromes. Callosal dysgenesis is a structural brain wiring disorder that can impact brain function and cognition in heterogeneous ways. We aim to understand how early developmental mechanisms lead to circuit alterations that ultimately impact behaviour and cognition. Translated to Spanish by MD and Medical interpreter Trinidad Ott. El cuerpo calloso es el tracto de fibras más grande del cerebro de los mamíferos placentarios y conecta los dos hemisferios cerebrales. La disgenesia del cuerpo calloso es un trastorno del desarrollo del cerebro que comunmente es genético y ocurre en aproximadamente 1: 4000 nacidos vivos. Se diagnostica fácilmente mediante resonancia magnética o ecografía prenatal y se encuentra aislado o junto con otras anomalías cerebrales, o con otros defectos del sistema de órganos en un gran número de síndromes congénitos diferentes. La disgenesia callosa es un trastorno estructural del cableado cerebral que puede afectar la función cerebral y la cognición de formas heterogéneas. Nuestro objetivo es comprender cómo los primeros mecanismos del desarrollo conducen a alteraciones en los circuitos que, en última instancia, afectan el comportamiento y la cognición. Traducción al español por la Doctora e Intérprete Médica Trinidad Ott.

Topics

MRIbehaviourbrain disordersbrain wiringcircuit alterationscognitioncongenital syndromescorpus callosumcortical developmentdysgenesismidline gliaprenatal ultrasoundstructural wiring

About the Speaker

Linda J. Richards AO, FAA, FAHMS, PhD.

Professor

Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

Contact & Resources

Personal Website

qbi.uq.edu.au/richardsgroup

@RichardsQBI

Follow on Twitter/X

twitter.com/RichardsQBI

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