Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Tuesday, April 22, 2025
06:00 UTC
Dr. Kenneth Hayworth
Carboncopies Foundation & BPF Aspirational Neuroscience
Recording
Open recording
Hosted by Carboncopies Foundation - Brain Emulation Challenge90 minutes
Abstract
Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala. This study by Marios Abatis et al. demonstrates how fear conditioning strengthens synaptic connections between engram cells in the lateral amygdala, revealed through optogenetic identification of neuronal ensembles and electrophysiological measurements. The work provides crucial insights into memory formation mechanisms at the synaptic level, with implications for understanding anxiety disorders and developing targeted interventions. Presented by Dr. Kenneth Hayworth, this journal club will explore the paper's methodology linking engram cell reactivation with synaptic plasticity measurements, and discuss implications for memory decoding research.
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