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Inconvenient Truth Pathophysiological Remodeling

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Seminar✓ Recording AvailableNeuroscience

An inconvenient truth: pathophysiological remodeling of the inner retina in photoreceptor degeneration

Michael Telias

Dr

University of Rochester

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Monday, April 7, 2025

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Monday, April 7, 2025

3:00 PM Asia/Tel_Aviv

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Host: BIU Vision Science

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BIU Vision Science

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Abstract

Photoreceptor loss is the primary cause behind vision impairment and blindness in diseases such as retinitis pigmentosa and age-related macular degeneration. However, the death of rods and cones allows retinoids to permeate the inner retina, causing retinal ganglion cells to become spontaneously hyperactive, severely reducing the signal-to-noise ratio, and creating interference in the communication between the surviving retina and the brain. Treatments aimed at blocking or reducing hyperactivity improve vision initiated from surviving photoreceptors and could enhance the signal fidelity generated by vision restoration methodologies.

Topics

age-related macular degenerationhyperactivityphotoreceptor degenerationretinal ganglion cellsretinitis pigmentosaretinoidssignal-to-noise ratiovision impairmentvision restoration

About the Speaker

Michael Telias

Dr

University of Rochester

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