Mechanisms to medicines in neurodegeneration
Schedule
Tuesday, November 30, 2021
15:00 UTC
Giovann Mallucci
Professor
Department of Clinical Neurosciences, University of Cambridge
Host: Cambridge Neuro
Recording
Open recording
Event Information
Recording
Available
Host
Cambridge Neuro
Duration
70 minutes
Abstract
Dysregulation of protein synthesis both globally and locally in neurons and astrocytes is a key feature of neurodegenerative diseases. Aberrant signalling through the Unfolded Protein Response (UPR) and related Integrated Stress Response (ISR) have become major targets for neuroprotection in these disorders. In addition, other homeostatic mechanisms and stress responses, including the cold shock response, appear to regulate local translation and RNA splicing to control synapse maintenance and regeneration and can also be targeted therapeutically for neuroprotection. We have defined the role of UPR/ISR and the cold-shock response in neurodegenerative disorders and have developed translational strategies targeting them for new treatments for dementia.
Topics
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