Dementia

This free hybrid conference connects emerging Alzheimer’s and dementia researchers and clinicians across molecular biology, genetics, drug development and related neuroscience. A live virtual core programme links local hubs in Bangkok, Cairo, Ljubljana and Nicosia, with mentoring, networking and career-development opportunities. All participants complete the global registration; those attending physically also complete a separate registration for their chosen hub.

…early-career investigators and the dementia-care research community together to share research across Alzheimer’s disease and other dementias. The meeting connects work on mechanisms and diagnosis with risk reduction, prevention, treatment and care. Presentations and discussion provide opportunities to compare emerging findings and research approaches across these areas. The 2027 meeting offers both Chicago and online participation. Abstract submissions are scheduled to open in autumn 2026, and registration in spring 2027. Present

…living with or likely to develop dementia, and added-value sub-studies across all phases of clinical trials. Studies integrate biological investigation with clinical intervention and may evaluate target engagement, brain penetrance and effects on disease biomarkers; sub-studies can cover trial development, coordinated biobanking and the collection of imaging, digital or other high-value trial data. Amount and duration are flexible and set by each proposal. Standalo

…of older adults’ depression and dementia that conventional clinical assessments miss. The session covers behavioural patterns, sleep disruption and treatment responses measured outside clinical settings, and considers how repeated observations can track changes in health over time. Guu also presents plans for a technology-enabled longitudinal cohort to study ageing populations over months and years, discussing how the resulting patterns could inform research and clinical practice. The session includes question

…and later health outcomes, including dementia and cardiovascular disease. The discussion concerns research findings and open questions rather than individual treatment recommendations.

…cognitive function in individuals with dementia. This technique leverages electroencephalography (EEG) to measure brain responses to rapidly presented visual stimuli, offering a non-invasive and objective method for evaluating a range of cognitive functions. Unlike traditional cognitive assessments, FPVS does not rely on behavioural responses, making it particularly suitable for individuals with cognitive impairment. In this talk I will highlight a series of studies that have demonstrated its ability to detec

…of mild cognitive impairment and/or dementia. Unfortunately, despite the increasin

…abilities can be a predictor of dementia. One of the numerical competence that can be studied in this area is the numerosity estimation ability, which is the basis for more complex mathematical operations, such as addition or multiplication. The purpose of the study was to test the relationship between different areas of cognitive functioning and selected numerical competence. The study participants were 72 elderly people (M = 71.00, SD = 4.90), w

…impairments and an increased risk of dementia. Social withdrawal due to difficulties in verbal interaction may play an important role. Previous research on deafened rats, ruling out language as a potential confounding factor, showed only initial and mild cognitive deficits during learning, whereas electrophysiological recordings in the prefrontal cortex revealed compromised neuronal activity to some extent. The present study tested whether hearing loss would lead to altered expression of the GABA and dopamine (DA) systems in key re

Dementia is characterised by a profound decline in cognitive and behavioural functions, drastically affecting daily life and social interactions. There is a pressing need for novel therapeutic strategies, particularly if these can be repurposed from available medicine – recent research has suggested antidiabetic drugs may have neuroprotective properties, but validation requires translatable pre-clinical models paired with unbiased assessment. Rocky Mountain Laboratory (RML) scrapie is a well-characterised model that mimics many of the hallmarks of neurodegeneration seen in dementia but does no

…cognitive conditions leading to dementia. However, previous studies have reported cognitively healthy patients with cortical tau pathologies. The mechanism for this cognitive protection in a tauopathy environment is being investigated by various groups. Astrocytes are essential for physiological homeostasis of brain and reactive astrogliosis is an associated pathology in neuroinflammation associated with TBI. The correlation between lev

Considering the difficulty in finding a reversible cure for dementia, research and clinical focus have shifted towards modifiable risk factors for cognitive decline, with sleep disturbances gaining attention especially in older adults with mild cognitive impairment (MCI). Given the significant impact of sleep disturbances on cognitive decline in MCI, this study explores the relationship between psychological factors, including depression, anxiety, and stress, and insomnia among older adults with MCI. 145 Greek older adults were recruited from an outpatient memory clinic in Athens. The sample m

…in increasing the risk of developing dementia and Alzheimer’s Disease (AD) with age, yet the intricate details of how TBI could increase the risk of such afflictions remain obscure. The scarcity of research in this area can be attributed partially to the lack of suitable animal models that can carry humanized versions of the genes known to pose a risk for developing AD. We used two cohorts of 6 months old mice, each consisting of 10 animals (5 males), carrying humanized versions of Amyloid Precursor Protein (APP), Tau

…risk factor for cognitive decline and dementia. This study investigates how the timing of depression onset—either early or late after a gastrointestinal (GI) disease diagnosis—affects the risk of developing dementia. A particular focus is placed on the heightened risk of depression in the immediate aftermath of a GI disorder diagnosis, examining how this timing relates to subsequent dementia risk. Utilizing a retrospective cohort analysis of 106,245 patients from the Korean National Health Insurance Service-Elderly database

The auditory loss is associated with increased cognitive deterioration and even dementia, including Alzheimer's Disease (AD). However, the relation between the cause of the auditory loss and the mechanism during AD is still unknown. One hypothesis is that social isolation after hearing loss could facilitate dementia. Still, it is also believed that AD itself could cause alterations in the auditory pathway and this alteration promotes cognitive deterioration. The auditory signal is transmitted along the auditory pathway in the form of action potentials through the auditory nerve and across the

Dementia is a prevalent and, based on severity, disabling neurocognitive disorder that primarily affects people older than 65 years of age. There is an increasingly emerging need to identify specific markers of dementia for interventions before disease progression. Irisin is a myokine produced during exercise with multiple effects on various organs, including a neuroprotective role on brain. Here, we investigated the involvement of irisin in patients with dementia biologically classified according to the Amyloid-β-Tau-Neurodegeneration classification system. Serum and cerebrospinal fluid (CSF)

Dementia is a term for several diseases that affect memory, thinking, and daily activity performance. The most prevalent form of dementia is Alzheimer’s disease (AD), which explains 60-70% of dementia cases (World Health Organization [WHO], 2023). AD is a neurodegenerative disorder characterized by brain atrophy, gliosis, Abeta and tau proteinopathies, and vascular dysfunction. Previously, our group has described that a non-productive angiogenesis (NPA) phenomenon occurs around Abeta plaques, giving rise to disassembled, low-perfused vascular structures, which we have called vascular scars (Va

…Alzheimer is the most current form of dementia, affecting millions of patients worldwide. As a neurodegenerative disease, it is associated with a progressive degradation process in the brain, leading to cognitive and functional impairment. Various forms of standard therapies are currently used to slow down the progression of the disease. However, their effective benefits and possible side effects should always be weighted up prior prescription. TPS is a relatively new drug-f

…Alzheimer’s disease and other form of dementia.

…It is sensitive to early dementia; language, education, effort and anxiety independent and can be used in any setting including patients’ homes. It can capture a range of cognitive functions including semantic memory, recognition memory, attention and visual function. We have shown that Fastball is sensitive to cognitive dysfunction in Alzheimer’s disease and Mild Cognitive Impairment, with data collected in patients’ homes using low-cost portable EEG. We are n

Ingebrigt Steen Jensen discusses his experience of dementia and the personal and social consequences of the diagnosis. Conversation in Norwegian.

…Alzheimer’s Disease and other forms of dementia. The elasticity of cerebral arteries is influenced by lifestyle factors, including cardiorespiratory fitness. Monica will discuss data obtained in their laboratory with ne

…normal and having full-blown Dementia, with every third person with MCI progressing to dementia of the Alzheimer's Type (DAT). While there is no known way to reverse symptoms once they begin, early prediction of d

In the United States, racial/ethnic inequalities in Alzheimer's disease and related dementias persist even after controlling for socioeconomic factors and physical health. These persistent and unexplained disparities suggest: (1) there are unrecognized dementia risk factors that are socially patterned and/or (2) known dementia risk factors exhibit differential impact across social groups. Pursuing these research directions with data from multiple longitudinal studies of brain and cognitive aging has revealed several challenges to the study of late-life health inequalities, highlighted evidence