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Cognitive Vulnerability in Late-onset Unexplained Epilepsy: Early Findings from the ELUCID Study

Alice D. Lam

Associate Professor of Neurology, Harvard Medical School, Mass General Brigham Neuroscience Institute

Abstract

Epilepsy is most common in older adults, and about 30% of late-onset cases have no identified cause. Alice Lam reviews epidemiological evidence linking late-onset unexplained epilepsy to cognitive decline and introduces ELUCID, a multicentre prospective longitudinal study of this epilepsy as a risk factor for cognitive impairment and dementia. Early results show heterogeneous cognitive performance, identify clinical factors associated with cognitive impairment and highlight the multidimensional nature of cognitive vulnerability in these patients.

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