Topic: cognitive impairment

It is challenging to create chemical-induced models of Alzheimer’s disease without using genetically bred animals. Intracerebroventricular (ICV) streptozocin (STZ) administration at a sub-diabetogenic dose can serve as a viable model for cognitive impairment associated with Alzheimer's disease via a disruption of glucose and energy metabolism in the brain, accompanied by oxidative stress and a concurrent impact on cognitive function. The aim of this study is to evaluate the behavioral results of once or twice injections of the ICV STZ administration methods. ICV guide cannulas were placed unil

Metabolic Syndrome (MetS) and obesity correlate with cognitive impairment, heightening the susceptibility to cognitive decline and dementia. Noteworthy, cognitive impairment exacerbates weight management challenges in MetS, giving rise to a "cognitive decline-MetS" loop. Indeed, various cognitive and affective functions, including memory and executive functions, were found to be compromised in MetS, with underlying mechanistic pathways supporting a potential role of oxy-inflammatory signaling.Our research delves into the nuanced realm of cognitive alterations in MetS by examining the correlati