Topic: cognitive decline

Considering the difficulty in finding a reversible cure for dementia, research and clinical focus have shifted towards modifiable risk factors for cognitive decline, with sleep disturbances gaining attention especially in older adults with mild cognitive impairment (MCI). Given the significant impact of sleep disturbances on cognitive decline in MCI, this study explores the relationship between psychological factors, including depression, anxiety, and stress, and insomnia among older adults with MCI. 145 Greek older adults were recruited from an outpatient memory clinic in Athens. The sample m

Dementia, a complex, incurable clinical syndrome marked by progressive cognitive decline, encompasses various types, with Alzheimer's disease (AD) being the most prevalent. The annual increase in AD cases underscores the urgency for innovative antidementia treatments. Mansorin A (MA) and mansonone G (MG) exhibit antioxidant effects on the central nervous system. Given the close association between oxidative stress and AD pathology, MA and MG might alleviate AD-like symptoms. To investigate the anti-dementia potential of MA and MG, the promnesic, anxiolytic, and antioxidant potential of MA and