Clinical Neurology ePosters

Recognizing the causes of ischemic stroke is crucial for defining secondary preventive strategies. Etiology-based classification systems integrate clinical, imaging, and laboratory findings to assign stroke etiology[1-4]. However, this requires significant time and resources, and these systems still fail to assign…

Transcranial direct current stimulation (tDCS) has proven to be effective in reducing the seizure frequency in patients with epilepsy. This therapy greatly benefits from designing personalized electrode montages (electrode positions and currents) that target the appropriate areas of the brain. In the state-of-the-art…

Burst-suppression (BS) is a highly structured electroencephalogram (EEG) pattern characterized by alternating periods of high-voltage activity (bursts) and low or flatline activity (suppression). In non-anesthetized adults, BS indicates severe brain pathology, e.g. due to oxygen and glucose deprivation [1]. There are…

The human language system comprises a series of processing stages across multiple brain regions typically lateralized to the left cerebral hemisphere. In the event of stroke or other injury to these systems, neural circuits reorganize in an attempt to restore lost function. However, the neural processes and learned…

The Ruhr Hand Motion Catalog of Human Center-Out Transport Trajectories [1] is a compilation of three-dimensional task-space motion data simultaneously measured by two motion tracking systems. The first one, an optical motion capture system, provided robust reference data. The second recording system consisted of a…

Advancing therapies for neurological disorders relies on developing efficient, personalized whole-brain models that can capture mechanistic insights and pathological features. Current challenges in creating such computational models arise from managing a considerable number of adjustable parameters. The conventional…

Familial hemiplegic migraine type 3 (FHM-3) is a type of migraine with aura, caused by gain-of-function mutations of NaV1.1 [1,2]. This voltage-gated channel is mainly expressed in fast-spiking inhibitory neurons as their dominant Na+ channel. Cortical spreading depolarization, a wave of hyperexcitability followed by…

White matter (WM) tracts shape the brain’s dynamical activity, and their damage (e.g., disconnections) results in functional alterations and cognitive symptoms [1]. Here, we use neural mass modeling to test the in-vivo effects of WM disconnections [2]. We create models of local versus global, and edge versus nodal…

The hippocampus (HC) plays a pivotal role in spatial navigation and memory in the human brain. Place cells, specialised neurons residing within the hippocampus, exhibit selective firing patterns corresponding to specific spatial locations, collectively contributing to the cognitive mapping of the environment. In…

Brain activity lies on a very complex network. This complexity is multiple but a prominent one is the non-linear and multi-factorial interaction between its nodes. In the specific case of Parkinson's disease (PD), the brain loses dopaminergic neurons in the substantia nigra compacta (SNc). Highly involved in the basal…

Parkinson's disease (PD), characterized by the absence of dopamine in the striatum[1], is caused by the death of the substantia nigra pars compacta dopamine (SNcDA) neurons in the midbrain. The loss of these autonomously pacemaking[2] neurons is attributed to irreparable damage due to a dysregulation cascade starting…

Deep Brain Stimulation (DBS) in the Globus Pallidus internus (GPi) is a therapeutic approach for various neurological disorders. Its effects on decision-making remain complex and not fully understood. The presented study uses a neuro-computational model of the basal ganglia to investigate how DBS influences…

Optogenetic inhibition of excitatory subpopulations of the hippocampus has been suggested as a new approach in the treatment of temporal lobe epilepsy (TLE), one of the most common types of drug-resistant epilepsy. While this approach is promising, its application in animal models has proven to be a challenge. This…

Wobble board-based Exergaming of different intensities provides a unique approach to enhance different cognitive and balance parameters . This study aims to determine that which of the cognitive and balance components are greatly affected by wobble board exergaming of different intensities in individuals with mild…

Wasteosomes (or corpora amylacea) appear in the human brain with advancing age and in some neurodegenerative diseases. They have been proposed to accumulate waste substances and to contribute to a brain-cleaning mechanism. In this context, wasteosomes may have the potential to entrap some of the proteins that misfold,…

Migraine is a recurrent headache disorder characterized by episodes of acute pain. The overall objective of this work, was to test the hypothesis that the NLRP3 inflammasome is involved in the pathophysiology of migraine and that NLRP3 blockade may represent a novel strategy for migraine management through the design…

The vestibular organ is an integral sensory systems designed to provide afferent information to the brain. Once integrated, efferent signals are transmitted to produce a motor output associated with gaze stabilization through compensatory eye movements, postural adjustments, and maintenance of static and dynamic…

Acute Ischemic Stroke (AIS) is a major cause of death and disability worldwide. Mechanical thrombectomy to remove clots from cerebral vasculature represents a unique opportunity to study characteristics and biological patterns of stroke pathophysiology. There is marked heterogeneity in clots and great interest in…

Dementia, a complex, incurable clinical syndrome marked by progressive cognitive decline, encompasses various types, with Alzheimer's disease (AD) being the most prevalent. The annual increase in AD cases underscores the urgency for innovative antidementia treatments. Mansorin A (MA) and mansonone G (MG) exhibit…

Neurofibromatosis type 1 (NF1) is one of the most prevalent rare genetic diseases, confronting patients with numerous medical (neurological, cutaneous, osseous) and neuropsychological symptoms. To identify risk factors and allow for targeted neuropsychological intervention, potential associations between the…

Objectives: We aim to investigate the impact of acute stroke on delta oscillation in STN and to explore the correlation between motor disability and the altered delta oscillation in STN following stroke. Methods: 10 Sprague-Dawley rat were included in this study. They were trained in single pellet reaching task before…

More pilot studies are emerging with the goal of contributing to the bigger puzzle of personalized multiple sclerosis (MS) therapies. This study aimed to examine the potential benefit of using four non-coding RNAs (ncRNAs) (miR-141, miR-9, MEG3, and IFNG-AS1) as prognostic and/or diagnostic biomarkers for MS. We also…

Multiple System Atrophy (MSA) is a progressive neurodegenerative disorder due to the loss of various neuronal populations, including the GABAergic and the dopaminergic systems in the striatum and in the midbrain. The resulting degeneration of the nigro-striatal circuit is responsible for a severe neurological…

Multiple Sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Despite advancements in diagnostic methods, early detection remains challenging. Metabolomic analysis offers a promising, non-invasive approach to identify potential biomarkers for improved diagnostic precision.Cerebrospinal…