Topic: recognition memory

Fast periodic visual stimulation (FPVS) has emerged as a promising tool for assessing cognitive function in individuals with dementia. This technique leverages electroencephalography (EEG) to measure brain responses to rapidly presented visual stimuli, offering a non-invasive and objective method for evaluating a range of cognitive functions. Unlike traditional cognitive assessments, FPVS does not rely on behavioural responses, making it particularly suitable for individuals with cognitive impairment. In this talk I will highlight a series of studies that have demonstrated its ability to detec

Fastball is a novel, fast, passive biomarker of cognitive function, that uses cheap, scalable electroencephalography (EEG) technology. It is sensitive to early dementia; language, education, effort and anxiety independent and can be used in any setting including patients’ homes. It can capture a range of cognitive functions including semantic memory, recognition memory, attention and visual function. We have shown that Fastball is sensitive to cognitive dysfunction in Alzheimer’s disease and Mild Cognitive Impairment, with data collected in patients’ homes using low-cost portable EEG. We are n

It has long been established that the hippocampus plays a crucial role for episodic memory. As opposed to the modular approach, now it is generally assumed that being a complex structure, the HC performs multiplex interconnected functions, whose hierarchical organization provides basis for the higher cognitive functions such as semantics-based encoding and retrieval. However, the «where, when and how» properties of distinct memory aspects within and outside the HC are still under debate. Here we used a visual associative memory task as a probe to test the hypothesis about the differential invo

The successful recognition of familiar persons is critical for social interactions. Despite extensive research on the neural representations of familiar faces, we know little about how such representations unfold as someone becomes familiar. In three EEG experiments, we elucidated how representations of face familiarity and identity emerge from different qualities of familiarization: brief perceptual exposure (Experiment 1), extensive media familiarization (Experiment 2) and real-life personal familiarization (Experiment 3). Time-resolved representational similarity analysis revealed that fami

When you hear two versions of the same event, you can either update the memory of the first version with information from the second (updating) or retain both separately (differentiation). Prediction errors, the deviation between expected and actual outcomes, are presumably involved in mediating the competition between these processes. However, the mechanisms underlying this competition remain unclear. Here, we present a Hopfield network model that aims to account for the results of a behavioral study of memory updating. Participants heard conversational stimuli that were modified relative t

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by early decline in episodic and spatial memory, associated with accumulation of brain markers. Intriguingly, despite similar levels of brain alteration, some elderly subjects show less cognitive impairment than others. To explain this lack of correlation between the degree of brain lesions and the severity of cognitive symptoms, the concept of cognitive resilience (CR) has emerged. Yet, the protective mechanisms supporting CR remain poorly understood. To tackle this issue, we developed a preclinical model of