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Gu Lab, Icahn School of Medicine at Mount Sinai
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Schedule
Wednesday, November 17, 2021
6:00 PM Europe/Berlin
Recording provided by the organiser.
Domain
NeuroscienceHost
WWNeuRise
Duration
35 minutes
Knowing where we are, where we have been, and where we are going is critical to many behaviors, including navigation and memory. One potential neuronal mechanism underlying this ability is phase precession, in which spatially tuned neurons represent sequences of positions by activating at progressively earlier phases of local network theta oscillations. Based on studies in rodents, researchers have hypothesized that phase precession may be a general neural pattern for representing sequential events for learning and memory. By recording human single-neuron activity during spatial navigation, we show that spatially tuned neurons in the human hippocampus and entorhinal cortex exhibit phase precession. Furthermore, beyond the neural representation of locations, we show evidence for phase precession related to specific goal states. Our find- ings thus extend theta phase precession to humans and suggest that this phenomenon has a broad func- tional role for the neural representation of both spatial and non-spatial information.
Salman Qasim
Gu Lab, Icahn School of Medicine at Mount Sinai
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