Selectively Silencing Nociceptor Sensory Neurons
Prof
Harvard Medical School
Event Information
Host
SONA
Duration
70 minutes
Abstract
Local anesthetics decrease the excitability of all neurons by blocking voltage-gated sodium channels non-selectively. We have developed a technology to silence only those sensory neurons – the nociceptors – that trigger pain, itch, and cough. I will tell you why and how we devised the strategy, the way we showed that it works, and will also discuss its implications for treating multiple human disorders.
Topics
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