Synapses, Shadows and Stress Contagion
Schedule
Monday, November 29, 2021
05:00 UTC
Jaideep Bains
Dr.
Professor, University of Calgary, Hotchkiss Brain Institute, Department of Physiology and Pharmacology
Host: Manitoba Neuroscience Network
Recording
Open recording
Event Information
Recording
Available
Host
Manitoba Neuroscience Network
Duration
70 minutes
Abstract
Survival is predicated on the ability of an organism to respond to stress. The reliability of this response is ensured by a synaptic architecture that is relatively inflexible (i.e. hard-wired). Our work has shown that in naive animals, synapses on CRH neurons in the paraventricular nucleus of the hypothalamus are very reluctant to modification. If animals are stressed, however, these synapses become willing to learn. This seminar will focus on mechanisms linking acute stress to metaplastic changes at glutamate synapses, and also show how stress, and these synaptic changes can be transmitted from one individual to another.
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