Paraventricular nucleus

…of angiotensin 1-7 (Ang 1-7) into the paraventricular nucleus of the hypothalamus (PVN) increased blood pressure (BP) via activation of Mas receptors, higher in hypertensive than normotensive rats (Mińczuk et al., Cells. 2022;11:1542). The aim of our current study was to explore potential mechanism(s) of the pressor response of Ang 1-7 injected into the PVN. Methods: Respective antagonists and Ang 1-7 were injected into the PVN of urethane-anesthetized Wistar rats. Results: Injection of Ang 1-7 (0.3 nmol/rat) into the P

The first and probably most important bond is between a mother and her infant promoting their psychological and physiological well-being. Here, the “pro-maternal” oxytocin system as well as the “anti-maternal” CRF system are strongly involved in the formation and maintenance of this maternal bond. Losing a child is a severely stressful experience that dramatically affects the maternal brain, and those neuropeptide systems are promising candidates concerning the underlying emotional and behavioral consequences. Our study endeavored to investigate the changes in rat mothers' CRF system activity

Tyrosine hydroxylase (TH) expressing neurons in the arcuate nucleus of hypothalamus (ARC), has a central role in regulating appetite and metabolism. It has been shown that activity changes in these neurons are necessary and sufficient to acutely regulate feeding behavior. TH neurons send dense intrahypothalamic axonal projections and make synaptic connections to paraventricular nucleus (PVN), which have been shown to be the key downstream target region. Since the ARCTH→PVN synaptic connection plays a crucial role in feeding, possible changes in the strength of this connection are also likely t

…oxytocin (OXT), produced in the paraventricular nucleus(PVN) and supraoptic nucleus(SON) of the hypoth

…synapses on CRH neurons in the paraventricular nucleus of the hypothalamus are very reluctant to modification. If animals are stressed, however, these synapses become willing to learn. This seminar will focus on mechanisms linking acute stress to metaplastic changes at glutamate synapses, and also show how stress, and these synaptic changes can be transmitted

…centrally released by hypothalamic paraventricular nucleus (PVN). Do experiences that induce maternal behavior act by engaging PVN oxytocin neurons? To answer this, we used virgin female mice, animals that in the wild live in