Autoimmune
autoimmune
The immunopathogenesis of autoimmune seizure disorders
Immune-mediated mechanisms are increasingly recognised as a cause of epilepsy even in the absence of an immune response against a specifical neuronal antigen. In some cases, these autoimmune processes are clearly pathogenic, for example acute seizures in autoimmune encephalitis, whereas in others this is less clear, for example autoimmune-associated epilepsy. Recent research has provided novel insights into the clinical, paraclinical and immunopathogenetic mechanisms in these conditions. I will provide an overview of clinical and paraclinical features of immune-associated seizures. Furthermore, I will describe specific immunopathogenic examples implicating lymphoid follicular autoimmunisation and intrathecal B cells in these conditions. These insights into immunopathogenesis may help to explain the role of current and immunotherapies in these conditions.
Autoimmune encephalitis
Astrocytic S100B protein in experimental autoimmune encephalomyelitis processes
FENS Forum 2024
Cannabinoid CB1 receptors in oligodendrocytes: Modulation of energy metabolism and autoimmune demyelination
FENS Forum 2024
Elucidating neuronal activity patterns in autoimmune neuroinflammation: A brain-wide approach
FENS Forum 2024
Ex-vivo and in-vivo analysis of hippocampal pathology in a murine model of anti-GABAB autoimmune encephalitis
FENS Forum 2024
Meningeal neural progenitors respond to central nervous system autoimmune disease and interact with immune cells
FENS Forum 2024
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis
FENS Forum 2024
Unveiling cortical microvascular dysfunction and neurodegeneration mechanisms in experimental autoimmune encephalomyelitis
FENS Forum 2024