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Cellular States
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cellular states
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SeminarNeuroscience
Fate and freedom in the developing mammalian brain
Denis Jabaudon
Unige
Nov 15, 2020
While the diversity of neurons in the adult mammalian brain is staggering, these cells emerge from a seemingly limited set of progenitors during development. This begs the question of how complexity emerges from a finite number of elements during dynamic biological processes. Here, I will discuss recent work from my laboratory addressing relationships between genetic diversity and connectivity in single-cell types, and how progenitor diversity may constrain adult brain cellular states during normal and abnormal brain development.