Endocannabinoid
endocannabinoid
Endocannabinoid System Dysregulations in Binge Eating Disorder and Obesity
Exploring the endocannabinoid system for intervention innovation in autism
Organization and control of hippocampal circuits in epilepsy
Basket cells are key GABAergic inhibitory interneurons that target the somata and proximal dendrites, enabling efficient control of the timing and rate of spiking of their postsynaptic targets. In all cortical circuits, there are two major types of basket cell that exhibit striking developmental, molecular, anatomical, and physiological differences. In this talk, I will discuss recent results that reveal the tightly coupled complementarity of these two key microcircuit regulatory modules, demonstrating a novel form of brain-state-specific segregation of inhibition during spontaneous behavior, with implications for the assessment of dysregulated inhibition in epilepsy. In addition, I will describe recent advances in our understanding of the spatio-temporal dynamics of endocannabinoid signaling in hippocampal circuits and discuss how abnormal amplification of these activity-dependent signaling processes leads to surprising downstream effects in seizures.
Targeting the Endocannabinoid System for Management of Chemotherapy, HIV and Antiretroviral-Induced Neuropathic Pain
Chemotherapeutic drugs (used for treating cancer), HIV infection and antiretroviral therapy (ART) can independently cause difficult-to-manage painful neuropathy. Paclitaxel, a chemotherapeutic drug, for example is associated with high incidence of peripheral neuropathy, around 71% of the patients of which 27% of these develop neuropathic pain. Use of cannabis or phytocannabinoids has been reported to improve pain measures in patients with neuropathic pain, including painful HIV-associated sensory neuropathy and cancer pain. Phytocannabinoids and endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), produce their effects via cannabinoid (CB) receptors, which are present both in the periphery and central nervous system. Endocannabinoids are synthesized in an “on demand” fashion and are degraded by various enzymes such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). Various studies, including those from our group, suggest that there are changes in gene and protein expression of endocannabinoid molecules during chemotherapy-induced neuropathic pain (CINP), HIV and antiretroviral-induced neuropathic pain. Analysis of endocannabinoid molecule expression in the brain, spinal cord and paw skin using LC-MS/MS show that there is a specific deficiency of the endocannabinoids 2-AG and/or anandamide in the periphery during CINP. Various drugs including endocannabinoids, cannabidiol, inhibitors of FAAH and MGL, CB receptor agonists, desipramine and coadministered indomethacin plus minocycline have been found to either prevent the development and/or attenuate established CINP, HIV and antiretroviral-induced neuropathic pain in a CB receptor-dependent manner. The results available suggest that targeting the endocannabinoid system for prevention and treatment of CINP, HIV-associated neuropathic pain and antiretroviral-induced neuropathic pain is a plausible therapeutic option.
Acute stress via retrograde endocannabinoid signaling disrupts engram ensemble specificity to generalize threat memory in mice
FENS Forum 2024
Behavioural control training promotes antidepressant/anxiolytic-like reversal of chronic stress-induced behavioural deficits: Endocannabinoidergic and prolactinergic mechanisms
FENS Forum 2024
Blunted TLR3-induced inflammatory gene expression in the prefrontal cortex of the valproic acid model of autism, an effect unaltered by increasing endocannabinoid tone
FENS Forum 2024
Changes in endocannabinoid-dependent synaptic plasticity in CA1 hippocampus of a mouse model of temporal lobe epilepsy
FENS Forum 2024
Differential modulation of the endocannabinoid system in binge eating disorder and obesity
FENS Forum 2024
Expression of the endocannabinoid system in the visual cortex: Implications for cannabinoid research
FENS Forum 2024
A novel form of endocannabinoid-mediated plasticity of tonic GABA inhibition
FENS Forum 2024
Omega-3 fatty acids potentiate the endocannabinoid-dependent synaptic plasticity lost after adolescent binge drinking in male mouse dentate gyrus
FENS Forum 2024
Potential strategy for the therapeutic regulation of the endocannabinoid system with interfering peptides that modulate SGIP1 binding
FENS Forum 2024
Stress-induced potentiation of post-surgical pain and associated alterations in the endocannabinoid system
FENS Forum 2024
Targeting the dysfunctional endocannabinoid system in Gulf War Illness
FENS Forum 2024