Extracellular Vesicles
extracellular vesicles
The role of extracellular vesicles in sickness and in health
Virus-like intercellular communication in the nervous system
The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain and mediates various forms of synaptic plasticity. We recently discovered that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestral to retroviruses such as HIV. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system that may underlie cognition and memory.
Characterizing nerve-derived extracellular vesicles: Potentials and pitfalls
FENS Forum 2024
Deciphering the role of specific membrane transporters in extracellular vesicles
FENS Forum 2024
Endogenous alpha-Synuclein is essential for the transfer of pathology by exosome-enriched extracellular vesicles, following inoculation with preformed fibrils in vivo
FENS Forum 2024
Extracellular vesicles: An exploration into the bi-directional crosstalk of endothelial cells and astrocytes at the blood-brain barrier
FENS Forum 2024
Extracellular vesicles from mesenchymal stem cells alter gut microbiota and improve neuroinflammation and motor impairment in rats with mild liver damage
FENS Forum 2024
Extracellular vesicles from hypothalamic astrocytes modify transcription factors of the leptin signaling pathway in proopiomelanocortin (POMC) neurons
FENS Forum 2024
Extracellular vesicles and transmission of α-synuclein pathology: From cellular models to diagnostic applications
FENS Forum 2024
Extracellular vesicles from poly I:C-infected airway epithelial cells mediate viral signaling in microglia: Implications for neuroinflammation
FENS Forum 2024
Extracellular vesicles from MSCs reverse neuroinflammation in cerebellum and restore motor coordination in hyperammonemic rats
FENS Forum 2024
IL-4-induced microglia-derived small extracellular vesicles exhibit cytoprotective effects against LPS-induced microglial damage through miR-191-5p
FENS Forum 2024
Involvement of glioblastoma-derived extracellular vesicles in promoting endothelial cell remodelling: Implications for glioblastoma tumour progression
FENS Forum 2024
Loss of neuroprotection in Alzheimer’s disease: Shedding light on BDNF receptor cleavage and its mirroring in extracellular vesicles
FENS Forum 2024
Mechanisms of spinocerebellar ataxia type 2 pathogenesis: Insights from small extracellular vesicles
FENS Forum 2024
Plasma extracellular vesicles from hyperammonemia rats induce neuroinflammation in the hippocampus and cognitive impairment in control rats
FENS Forum 2024
Post-transcriptional regulation of neurodevelopment mediated by extracellular vesicles
FENS Forum 2024
Therapeutic effect of extracellular vesicles derived from mesenchymal stem cells in amyotrophic lateral sclerosis
FENS Forum 2024