Dr. Katie Kindt

A staff scientist position is available within the Section on Sensory Cell Development and Function at the National Institute on Deafness and Other Communication Disorders (NIDCD), at the National Institutes of Health (NIH). We are located in the multidisciplinary Neuroscience Research Center (Building 35A) in Bethesda, Maryland just outside of Washington D.C. Our group utilizes the zebrafish system to study hair cells, the specialized mechanoreceptors that are required to reliably transmit auditory and vestibular information to the brain. Specifically, we use this in vivo model to investigate the function and assembly of the hair cell system. Our work uses this relevant model by combining powerful genetics, functional and time-lapse imaging, electrophysiology, and behavioral analyses to comprehensively dissect the molecular and functional requirements underlying the assembly and function of hair cell systems in vivo. The main questions we are currently asking include: 1) how do collections of sensory cells, synapses, and neurons coordinate to encode sensory information; 2) how does sensory activity impact circuit assembly, function and health; and 3) what molecules are required to set up sensory function and synapse specificity?

Silvio P. Sabatini

The position is a full-time PhD studentship for a period of 3 years, starting on Nov 1st, 2023. The research project is titled 'Early vision function in silico networks of LIF neurons'. The project aims to develop an 'artificial observer' composed of an active event-based camera feeding a neuromorphic multi-layer network of leaky integrate and fire (LIF) neurons. The system should provide the inference engines for relating visual representations to performance on perceptual judgement tasks. Multiple and varying parameters captured under complex, real-life conditions should be comparatively assessed in silicon and human observers. The research will be conducted at the Bioengineering/PSPC labs of DIBRIS.

Dr. Ziad Nahas

Dr. Ziad Nahas (Interventional Psychiatry Lab) in the University of Minnesota Department of Psychiatry and Behavioral Sciences is seeking an outstanding candidate for a postdoctoral position to conduct and analyze the effects of neuromodulation on brain activity in mood disorders. Candidates should be passionate about advancing knowledge in the area of translational research of depressive disorders and other mental health conditions with a focus on invasive and non-invasive brain stimulation treatments. The position is available June 1, 2023, and funding is available for at least two years.

Dr. Ziad Nahas

Dr. Ziad Nahas (Interventional Psychiatry Lab) in the University of Minnesota Department of Psychiatry and Behavioral Sciences is seeking an outstanding candidate for a postdoctoral position to conduct and analyze the effects of neuromodulation on brain activity in mood disorders. Candidates should be passionate about advancing knowledge in the area of translational research of depressive disorders and other mental health conditions with a focus on invasive and non-invasive brain stimulation treatments. The position is available June 1, 2023, and funding is available for at least two years.

Prof. Dr. Tobias Rose

The selected candidate will investigate the 'Encoding of Landmark Stability and Stability of Landmark Encoding'. You will study visual landmark encoding at the intersection of hippocampal, thalamic, and cortical inputs to retrosplenial cortex. You will use cutting-edge miniature two-photon Ca2+ imaging, enabling you to longitudinally record activity in defined, large neuronal populations and long-range afferents in freely moving animals. You will carry out rigorous neuronal and behavioral analyses within the confines of automatized closed-loop tasks tailored for visual navigation. This will involve the application of advanced tools for dense behavioral quantification, including multi-angle videography, inertial motion sensing, and egocentric recording with head-mounted cameras for the reconstruction of retinal input. Our aim is to gain a comprehensive understanding of the immediate and sustained multi-area neuronal representation of visual landmarks during unrestricted behavior. We aim to elucidate the mechanisms through which stable visual landmarks are encoded and the processes by which these representations are stabilized to facilitate robust allocentric navigation.

Prof. Jim Torresen

The goal of the position is to create prediction methods for proactive planning of future robot actions and to design robot acting mechanisms for adaptive response ranging from quick and intuitive to slower well-reasoned. We combine sensing across multiple modalities with learned knowledge to predict outcomes and choose the best actions. The goal is to transfer these skills to human-robot interaction in home scenarios, including the support of everyday tasks and physical rehabilitation. Thus, it is relevant to work with implementation and research within robot perception and control for the robot tasks. User studies through human-robot interaction experiments are to be performed. A PhD fellow and a researcher are already hired for the project and will complement in performing the above outlined research.

Angelo Cangelosi

Two Research Fellows in Robotics / Human Robot Interaction are required for a period of 12 months each to work on the UKRI/EPSRC project “Trustworthy Autonomous Systems Node on Trust”. This is a collaborative project of the University of Manchester’s Cognitive Robotics Lab with Heriot-Watt University Edinburgh and Imperial College London. The candidates will carry out research on robot cognitive architectures for theory of mind and trust, using a combination of machine learning and robotics methodologies, and/or human-robot interaction for trust. The research fellows will be working collaboratively as part of the Cognitive Robotics Lab at the Department of Computer Science at the University of Manchester under the supervision of Professor Angelo Cangelosi. Close collaboration with the other project partners will also be required.

Prof. Jim Torresen

The goal of the position is to create prediction methods for proactive planning of future robot actions and to design robot acting mechanisms for adaptive response ranging from quick and intuitive to slower well-reasoned. We combine sensing across multiple modalities with learned knowledge to predict outcomes and choose the best actions. The goal is to transfer these skills to human-robot interaction in home scenarios, including the support of everyday tasks and physical rehabilitation. Thus, it is relevant to work with implementation and research within robot perception and control for the robot tasks. User studies through human-robot interaction experiments are to be performed. A PhD fellow and a researcher are already hired for the project and will complement in performing the above outlined research.

Vinita Samarasinghe

The research group uses diverse computational modeling approaches, including biological neural networks, cognitive modeling, and machine learning/artificial intelligence, to study learning and memory. The group is actively seeking a talented graduate student to join the team, who will expand the computational modeling framework Cobel-RL (https://doi.org/10.3389/fninf.2023.1134405) and use it to study how episodic memory might be used to learn to navigate.

Jens Peter Lindemann

The PhD project is part of the DFG-funded project 'Cue integration by bumblebees during navigation in uncertain environments with multiple goal options: Behavioural analysis in virtual reality and computational modelling' in an international research team. Bumblebees can be trained to prefer certain places or objects in a virtual environment through appropriate rewarding. In a close integration of two PhD projects, one with a focus on VR behaviour experiments and the other focussing on computational modelling and simulation, we are investigating the mechanisms underlying these learning and orientation performances. The applicant is expected to design and implement models for behavioral control of bumblebees, test them in computer simulations, contribute to VR experiments with bumblebees, and collaborate intensively with other project participants.

Mathieu Desroches

The aim of the project is to develop a multiscale model of Dravet syndrome, from ionic channels of interacting neurons to large neural populations. We will use various modeling frameworks, adapted to the scale, from piecewise-deterministic Markov processes to mean-field formalism. The postdoc will perform a mathematical analysis of the models, extensive numerical simulations as well as data analysis using neural recordings from our experimental partners.

Mathieu Desroches

The aim of the project is to develop a multiscale model of Dravet syndrome, from ionic channels of interacting neurons to large neural populations. We will use various modeling frameworks, adapted to the scale, from piecewise-deterministic Markov processes to mean-field formalism. The postdoc will perform a mathematical analysis of the models, extensive numerical simulations as well as data analysis using neural recordings from our experimental partners.

Antonio C. Roque

The Research, Innovation and Dissemination Center for Neuromathematics (NeuroMat), hosted by the University of São Paulo (USP), Brazil, and funded by the São Paulo Research Foundation (FAPESP), is offering post-doctoral fellowships for recent PhDs with outstanding research potential. The fellowship will involve collaborations with research teams and laboratories associated with NeuroMat. The research to be developed by the post-doc fellow shall be strictly related to ongoing research lines developed by the NeuroMat team that can be consulted at our website. The project may be developed at the laboratories of USP, campuses of São Paulo or Ribeirão Preto, or at UNICAMP, Campinas, in person.

Joseph Lizier

The successful candidates will join a dynamic interdisciplinary collaboration between A/Prof Mac Shine (Brain and Mind Centre), A/Prof Joseph Lizier (School of Computer Science) and Dr Ben Fulcher (School of Physics), within the University's Centre for Complex Systems, focused on advancing our understanding of brain function and cognition using cutting-edge computational and neuroimaging techniques at the intersection of network neuroscience, dynamical systems and information theory. The positions are funded by a grant from the Australian Research Council 'Evaluating the Network Neuroscience of Human Cognition to Improve AI'.

Ioan Marius BILASCO

The FOX team from the CRIStAL laboratory (UMR CNRS), Lille France and the PR team from the MIS Laboratory, Amiens France are looking to recruit a joint PhD student for a project titled 'EventSpike - Asynchronous computer vision from event cameras'. The project aims to develop new models of spiking neural networks (SNN) capable of directly processing visual information in the form of spike trains for applications in autonomous driving. The thesis will focus on weakly supervised learning methods based on spiking learning mechanisms to exploit the flow of impulses generated by an event camera.

Dr. Romy Lorenz

The Cognitive Neuroscience & Neurotechnology group at the Max Planck Institute for Biological Cybernetics, led by Dr. Romy Lorenz, is seeking two ambitious PhD students to work on the field of ultrahigh resolution fMRI for investigating the human cortex at the scale of layers and columns. The lab focuses on understanding the frontoparietal brain network mechanisms underpinning high-level cognition and adaptive behaviour through an interdisciplinary research programme. Methodologies include subject-specific brain-computer interface technology, fMRI at 3T and ultrahigh magnetic field strengths (7T and 9.4T), EEG, non-invasive brain stimulation, and machine learning.

N/A

The PostDoctoral researcher will conduct research activities in modelling and simulation of reward-modulated prosocial behavior and decision-making. The position is part of a larger effort to uncover the computational and mechanistic bases of prosociality and empathy at the behavioral and circuit levels. The role involves working at the interface between experimental data (animal behavior and electrophysiology) and theoretical modelling, with an emphasis on Multi-Agent Reinforcement Learning and neural population dynamics.

Rania Rayyes

The research in the AI & Robotics group focuses on developing novel AI systems for real robot applications for manipulation tasks, e.g., grasping, pin-picking. Areas of focus include Autonomous Robot Learning (active learning, lifelong learning, intrinsic motivation) and Human-Robot Learning (imitation learning, interactive learning).

Dr. Udo Ernst

In this project we want to study organization and optimization of flexible information processing in neural networks, with specific focus on the visual system. You will use network modelling, numerical simulation, and mathematical analysis to investigate fundamental aspects of flexible computation such as task-dependent coordination of multiple brain areas for efficient information processing, as well as the emergence of flexible circuits originating from learning schemes which simultaneously optimize for function and flexibility. These studies will be complemented by biophysically realistic modelling and data analysis in collaboration with experimental work done in the lab of Prof. Dr. Andreas Kreiter, also at the University of Bremen. Here we will investigate selective attention as a central aspect of flexibility in the visual system, involving task-dependent coordination of multiple visual areas.

N/A

The hired postdoctoral researcher will mainly work on WP2, i.e., on the development of new formalisms and methods to apply to higher order interaction patterns identified in the data analyzed in WP1. The project aims to build a theoretical and data analysis framework to demonstrate the role of higher-order interactions (HOIs) in human brain networks supporting causal learning. The Hinteract project includes three scientific work packages (WPs): WP1 focuses on developing an informational theoretical approach to infer task-related HOIs from neural time series and characterizing HOIs supporting causal learning using MEG and SEEG data. WP2 involves developing a network science formalism to analyze the structure and dynamics of functional HOIs patterns and characterizing the hierarchical organization of learning-related HOIs. WP3 is about compiling and sharing neuroinformatics tools developed in the project and making them interoperable with the EBRAINS infrastructure.

Pranav Nerurkar

Join our comprehensive online internship program focusing on Two Sample Hypothesis Testing, designed for students eager to delve into the world of statistical analysis and coding. This internship offers a unique blend of theoretical learning and practical application, providing participants with a robust understanding of hypothesis testing using real-world data. Key features include Interactive Video Lectures, Hands-On Coding Assignments, Practical Applications, Mentorship and Support, and Certification.

Ekta Vats

A fully funded PhD position in Machine Learning and Computer Vision is available at Uppsala University, Sweden. The position is a part of the Beijer Laboratory for Artificial Intelligence Research, funded by Kjell and Märta Beijer Foundation. In this project you will join us in conducting fundamental machine learning research and developing principled foundations of vision-language models, with opportunities to validate the methods on challenging real-world problems involving computer vision.

Genetic and epigenetic underpinnings of neurodegenerative disorders

Pluripotent cells, including embryonic stem (ES) and induced pluripotent stem (iPS) cells, are used to investigate the genetic and epigenetic underpinnings of human diseases such as Parkinson’s, Alzheimer’s, autism, and cancer. Mechanisms of somatic cell reprogramming to an embryonic pluripotent state are explored, utilizing patient-specific pluripotent cells to model and analyze neurodegenerative diseases.

Astrocyte reprogramming / activation and brain homeostasis

Astrocytes are multifunctional glial cells, implicated in neurogenesis and synaptogenesis, supporting and fine-tuning neuronal activity and maintaining brain homeostasis by controlling blood-brain barrier permeability. During the last years a number of studies have shown that astrocytes can also be converted into neurons if they force-express neurogenic transcription factors or miRNAs. Direct astrocytic reprogramming to induced-neurons (iNs) is a powerful approach for manipulating cell fate, as it takes advantage of the intrinsic neural stem cell (NSC) potential of brain resident reactive astrocytes. To this end, astrocytic cell fate conversion to iNs has been well-established in vitro and in vivo using combinations of transcription factors (TFs) or chemical cocktails. Challenging the expression of lineage-specific TFs is accompanied by changes in the expression of miRNAs, that post-transcriptionally modulate high numbers of neurogenesis-promoting factors and have therefore been introduced, supplementary or alternatively to TFs, to instruct direct neuronal reprogramming. The neurogenic miRNA miR-124 has been employed in direct reprogramming protocols supplementary to neurogenic TFs and other miRNAs to enhance direct neurogenic conversion by suppressing multiple non-neuronal targets. In our group we aimed to investigate whether miR-124 is sufficient to drive direct reprogramming of astrocytes to induced-neurons (iNs) on its own both in vitro and in vivo and elucidate its independent mechanism of reprogramming action. Our in vitro data indicate that miR-124 is a potent driver of the reprogramming switch of astrocytes towards an immature neuronal fate. Elucidation of the molecular pathways being triggered by miR-124 by RNA-seq analysis revealed that miR-124 is sufficient to instruct reprogramming of cortical astrocytes to immature induced-neurons (iNs) in vitro by down-regulating genes with important regulatory roles in astrocytic function. Among these, the RNA binding protein Zfp36l1, implicated in ARE-mediated mRNA decay, was found to be a direct target of miR-124, that be its turn targets neuronal-specific proteins participating in cortical development, which get de-repressed in miR-124-iNs. Furthermore, miR-124 is potent to guide direct neuronal reprogramming of reactive astrocytes to iNs of cortical identity following cortical trauma, a novel finding confirming its robust reprogramming action within the cortical microenvironment under neuroinflammatory conditions. In parallel to their reprogramming properties, astrocytes also participate in the maintenance of blood-brain barrier integrity, which ensures the physiological functioning of the central nervous system and gets affected contributing to the pathology of several neurodegenerative diseases. To study in real time the dynamic physical interactions of astrocytes with brain vasculature under homeostatic and pathological conditions, we performed 2-photon brain intravital imaging in a mouse model of systemic neuroinflammation, known to trigger astrogliosis and microgliosis and to evoke changes in astrocytic contact with brain vasculature. Our in vivo findings indicate that following neuroinflammation the endfeet of activated perivascular astrocytes lose their close proximity and physiological cross-talk with vasculature, however this event is at compensated by the cross-talk of astrocytes with activated microglia, safeguarding blood vessel coverage and maintenance of blood-brain integrity.

Epigenomic (re)programming of the brain and behavior by ovarian hormones

Rhythmic changes in sex hormone levels across the ovarian cycle exert powerful effects on the brain and behavior, and confer female-specific risks for neuropsychiatric conditions. In this talk, Dr. Kundakovic will discuss the role of fluctuating ovarian hormones as a critical biological factor contributing to the increased depression and anxiety risk in women. Cycling ovarian hormones drive brain and behavioral plasticity in both humans and rodents, and the talk will focus on animal studies in Dr. Kundakovic’s lab that are revealing the molecular and receptor mechanisms that underlie this female-specific brain dynamic. She will highlight the lab’s discovery of sex hormone-driven epigenetic mechanisms, namely chromatin accessibility and 3D genome changes, that dynamically regulate neuronal gene expression and brain plasticity but may also prime the (epi)genome for psychopathology. She will then describe functional studies, including hormone replacement experiments and the overexpression of an estrous cycle stage-dependent transcription factor, which provide the causal link(s) between hormone-driven chromatin dynamics and sex-specific anxiety behavior. Dr. Kundakovic will also highlight an unconventional role that chromatin dynamics may have in regulating neuronal function across the ovarian cycle, including in sex hormone-driven X chromosome plasticity and hormonally-induced epigenetic priming. In summary, these studies provide a molecular framework to understand ovarian hormone-driven brain plasticity and increased female risk for anxiety and depression, opening new avenues for sex- and gender-informed treatments for brain disorders.

Circuit solutions for programming actions

The hippocampus is one of the few regions in the adult mammalian brain which is endowed with life-long neurogenesis. Despite intense investigation, it remains unclear how neurons newly-generated may retain unique functions that contribute to modulate hippocampal information processing and cognition. In this talk, I will present some recent findings revealing how enhanced forms of plasticity in adult-born neurons underlie the way they become incorporated into pre-existing networks in response to experience.

Cell-type specific genomics and transcriptomics of HIV in the brain

Exploration of genome organization and function in the HIV infected brain is critical to aid in the understanding and development of treatments for HIV-associated neurocognitive disorder (HAND). Here, we applied a multiomic approach, including single nuclei transcriptomics, cell-type specific Hi-C 3D genome mapping, and viral integration site sequencing (IS-seq) to frontal lobe tissue from HIV-infected individuals with encephalitis (HIVE) and without encephalitis (HIV+). We observed reorganization of open/repressive (A/B) compartment structures in HIVE microglia encompassing 6.4% of the genome with enrichment for regions containing interferon (IFN) pathway genes. 3D genome remodeling was associated with transcriptomic reprogramming, including down-regulation of cell adhesion and synapse-related functions and robust activation of IFN signaling and cell migratory pathways, and was recapitulated by IFN-g stimulation of cultured microglial cells. Microglia from HIV+ brains showed, to a lesser extent, similar transcriptional alterations. IS-seq recovered 1,221 integration sites in the brain that were enriched for chromosomal domains newly mobilized into a permissive chromatin environment in HIVE microglia. Viral transcription, which was detected in 0.003% of all nuclei in HIVE brain, occurred in a subset of highly activated microglia that drove differential expression in HIVE. Thus, we observed a dynamic interrelationship of interferon-associated 3D genome and transcriptome remodeling with HIV integration and transcription in the brain.

Reprogramming the nociceptive circuit topology reshapes sexual behavior in C. elegans

In sexually reproducing species, males and females respond to environmental sensory cues and transform the input into sexually dimorphic traits. Yet, how sexually dimorphic behavior is encoded in the nervous system is poorly understood. We characterize the sexually dimorphic nociceptive behavior in C. elegans – hermaphrodites present a lower pain threshold than males in response to aversive stimuli, and study the underlying neuronal circuits, which are composed of the same neurons that are wired differently. By imaging receptor expression, calcium responses and glutamate secretion, we show that sensory transduction is similar in the two sexes, and therefore explore how downstream network topology shapes dimorphic behavior. We generated a computational model that replicates the observed dimorphic behavior, and used this model to predict simple network rewirings that would switch the behavior between the sexes. We then showed experimentally, using genetic manipulations, artificial gap junctions, automated tracking and optogenetics, that these subtle changes to male connectivity result in hermaphrodite-like aversive behavior in-vivo, while hermaphrodite behavior was more robust to perturbations. Strikingly, when presented with aversive cues, rewired males were compromised in finding mating partners, suggesting that the network topology that enables efficient avoidance of noxious cues would have a reproductive "cost". To summarize, we present a deconstruction of a sex-shared neural circuit that affects sexual behavior, and how to reprogram it. More broadly, our results are an example of how common neuronal circuits changed their function during evolution by subtle topological rewirings to account for different environmental and sexual needs.

Using Human Stem Cells to Uncover Genetic Epilepsy Mechanisms

Reprogramming somatic cells to a pluripotent state via the induced pluripotent stem cell (iPSC) method offers an increasingly utilized approach for neurological disease modeling with patient-derived cells. Several groups, including ours, have applied the iPSC approach to model severe genetic developmental and epileptic encephalopathies (DEEs) with patient-derived cells. Although most studies to date involve 2-D cultures of patient-derived neurons, brain organoids are increasingly being employed to explore genetic DEE mechanisms. We are applying this approach to understand PMSE (Polyhydramnios, Megalencephaly and Symptomatic Epilepsy) syndrome, Rett Syndrome (in collaboration with Ben Novitch at UCLA) and Protocadherin-19 Clustering Epilepsy (PCE). I will describe our findings of robust structural phenotypes in PMSE and PCE patient-derived brain organoid models, as well as functional abnormalities identified in fusion organoid models of Rett syndrome. In addition to showing epilepsy-relevant phenotypes, both 2D and brain organoid cultures offer platforms to identify novel therapies. We will also discuss challenges and recent advances in the brain organoid field, including a new single rosette brain organoid model that we have developed. The field is advancing rapidly and our findings suggest that brain organoid approaches offers great promise for modeling genetic neurodevelopmental epilepsies and identifying precision therapies.

Analysis and manipulation of facilitators and barriers of cell identity reprogramming

Novel mechanisms of neurogenesis and neural repair

In order to re-install neurogenesis after loss of neurons upon injury or neurodegeneration, we need to understand the basic principles of neurogenesis. I will first discuss about our discovery of a novel centrosome protein (Camargo et al., 2019) and discuss unpublished work about the great diversity of interphase centrosome proteomes and their relevance for neurodevelopmental disorders. I would then present work on a master regulator of neural stem cell amplification and brain folding (Stahl et al., 2013; Esgleas et al., 2020) to proceed presenting data on utilizing some of these factors for turning astrocytes into neurons. I will present data on the critical role of mitochondria in this conversion process (Gascon et al., 2016, Russo et al., 2020) and how it regulates the speed of conversion also showing unpublished data. If time permits I may touch on recent progress in in vivo reprogramming (Mattugini et al., 2019). Taken together, these data highlight the surprising specificity and importance of organelle diversity from centrosome, nucleolus and mitochondria as key regulators in development and reprogramming.

Epigenetic Reprogramming of Taste by Diet

Diets rich in sugar, salt, and fat alter taste perception and food intake, leading to obesity and metabolic disorders, but the molecular mechanisms through which this occurs are unknown. Here we show that in response to a high sugar diet, the epigenetic regulator Polycomb Repressive Complex 2.1 (PRC2.1) persistently reprograms the sensory neurons of D. melanogaster flies to reduce sweet sensation and promote obesity. In animals fed high sugar, the binding of PRC2.1 to the chromatin of the sweet gustatory neurons is redistributed to repress a developmental transcriptional network that modulates the responsiveness of these cells to sweet stimuli, reducing sweet sensation. Importantly, half of these transcriptional changes persist despite returning the animals to a control diet, causing a permanent decrease in sweet taste. Our results uncover a new epigenetic mechanism that, in response to the dietary environment, regulates neural plasticity and feeding behavior to promote obesity.

The thalamus that speaks to the cortex: spontaneous activity in the developing brain

Our research team runs several related projects studying the cellular and molecular mechanisms involved in the development of axonal connections in the brain. In particular, our aim is to uncover the principles underlying thalamocortical axonal wiring, maintenance and ultimately the rewiring of connections, through an integrated and innovative experimental programme. The development of the thalamocortical wiring requires a precise topographical sorting of its connections. Each thalamic nucleus receives specific sensory information from the environment and projects topographically to its corresponding cortical. A second level of organization is achieved within each area, where thalamocortical connections display an intra-areal topographical organization, allowing the generation of accurate spatial representations within each cortical area. Therefore, the level of organization and specificity of the thalamocortical projections is much more complex than other projection systems in the CNS. The central hypothesis of our laboratory is that thalamocortical input influences and maintains the functional architecture of the sensory cortices. We also believe that rewiring and plasticity events can be triggered by activity-dependent mechanisms in the thalamus. Three major questions are been focused in the laboratory: i) the role of spontaneous patterns of activity in thalamocortical wiring and cortical development, ii) the role of the thalamus and its connectivity in the neuroplastic cortical changes following sensory deprivation, and iii) reprogramming thalamic cells for sensory circuit restoration. Within these projects we are using several experimental programmes, these include: optical imaging, manipulation of gene expression in vivo, cell and molecular biology, biochemistry, cell culture, sensory deprivation paradigms and electrophysiology. The results derived from our investigations will contribute to our understating of how reprogramming of cortical wiring takes place following brain damage and how cortical structure is maintained.

Exploring the impact of partial reprogramming on astrocyte biology and its implications for brain homeostasis and aging

FENS Forum 2024

Innovative models for amyotrophic lateral sclerosis research: Dermal fibroblasts and direct cell reprogramming

FENS Forum 2024

Molecular reprogramming of engram cells rescues memory in AD

FENS Forum 2024

Tumor tissue metabolomics informs metabolic reprogramming in IDH wild-type gliomas

FENS Forum 2024