Over the last 20 years, neuroimaging and electrophysiology techniques have become central to understanding the mechanisms that accompany loss and recovery of consciousness. Much of this research is performed in the context of healthy individuals with neurotypical brain dynamics. Yet, a true understanding of how consciousness emerges from the joint action of neurons has to account for how severely pathological brains, often showing phenotypes typical of unconsciousness, can nonetheless generate a subjective viewpoint. In this presentation, I will start from the context of Disorders of Consciousness and will discuss recent work aimed at finding generalizable signatures of consciousness that are reliable across a spectrum of brain electrophysiological phenotypes focusing in particular on the notion of edge-of-chaos criticality.

The Department of Engineering Mathematics at the University of Bristol is seeking an outstanding candidate to fill the role of Professor in Artificial Intelligence. You will have the opportunity to provide visionary leadership to the department and its staff, students, & partners, helping to strengthen and further develop our already impressive research and teaching programs in AI. Our Intelligent Systems Group supports the Faculty of Engineering's AI/Data Science Theme, fostering an inclusive environment for all.

Head of a new research group and member of the Centre Board for a Senior Lecturer Autonomous Learning Systems and Reinforcement Learning (incl. responsibility in research & leadership) 50 - 100 %.

The job is a W3 Full Professorship for Artificial Intelligence in interactive Systems at Technische Universität Braunschweig. The role involves expanding the research area of data-driven methods for interactive and intelligent systems at the TU Braunschweig and strengthening the focal points 'Data Science' and 'Reliability' of the Department of Computer Science. The position holder is expected to have a strong background in Computer Science with a focus on Artificial Intelligence/​Machine Learning, specifically in the areas of Dependable AI and Explainable AI. The role also involves teaching, topic-related courses in the areas of Artificial Intelligence and Machine Learning to complement the Bachelor's and Master's degree programs of the Department of Computer Science.

This is a university doctoral position that involves minor teaching duties. The precise research topics are negotiable within the scope of active research at IIS, including machine learning and growing levels of AI for computer vision and robotics. Of particular interest are topics in representation learning and causality for out-of-distribution situations.

The Research Training Group 2853 “Neuroexplicit Models of Language, Vision, and Action” is looking for 3 PhD students and 1 postdoc. Neuroexplicit models combine neural and human-interpretable (“explicit”) models in order to overcome the limitations that each model class has separately. They include neurosymbolic models, which combine neural and symbolic models, but also e.g. combinations of neural and physics-based models. In the RTG, we will improve the state of the art in natural language processing (“Language”), computer vision (“Vision”), and planning and reinforcement learning (“Action”) through the use of neuroexplicit models and investigate the cross-cutting design principles of effective neuroexplicit models (“Foundations”).

The position holder will be a member of the Hessian Center for Artificial Intelligence - hessian.AI and provides research at the Center and will also be a member of the Centre for Cognitive Science. The scientific focus of the position is on the computational and algorithmic modeling of behavioral data to understand the human mind. Exemplary research topics include computational level models of perception, cognition, decision making, action, and learning as well as extended behavior and social interactions in humans, algorithmic models that are able to simulate, predict, and explain human behavior, model-driven behavioral research on human cognition. The professorship is expected to strengthen the Hessian Center for Artificial Intelligence and TU Darmstadt’s Human Science department’s research focus on Cognitive Science. Depending on the candidate’s profile there is the opportunity to participate in joint research projects currently running at TU Darmstadt. This in particular includes the state funded cluster projects “The Adaptive Mind (TAM)” and “The Third Wave of Artificial Intelligence (3AI)”. In addition to excellent scientific credentials, we seek a strong commitment to teaching in the department’s Bachelor and Masters programs in Cognitive Science. Experience in attracting third-party funding as well as participation in academic governance is expected.

We are seeking highly qualified and motivated individuals for the positions of Assistant and Associate Professors in Artificial Intelligence (AI) and Machine Learning (ML). The successful candidate will join our esteemed faculty in the Institute for Advancing Intelligence (IAI), TCG Centre for Research and Education in Science and Technology (CREST), Kolkata, India, and contribute to our commitment to excellence in research, teaching, and academic services. TCG CREST has set up the campus in Sector V, Salt Lake City, Kolkata, India. State-of-the-art laboratories and research facilities for the individual Institutes, spacious classrooms and technology interventions for executing both off-line and on-line academic classes and programs, conference rooms, and other infrastructures provide the students and the faculty an ideal environment for creative exchanges and high-end research collaborations.

SISSA is an elite postgraduate research institution for Maths, Physics and Neuroscience, located in Trieste, Italy. The Cognitive Neuroscience Department hosts 7 research labs that study the neuronal bases of time and magnitude processing, visual perception, motivation and intelligence, language and reading, tactile perception and learning, and neural computation. The Department is highly interdisciplinary; our approaches include behavioural, psychophysics, and neurophysiological experiments with humans and animals, as well as computational, statistical and mathematical models.

We are looking for a scientist who will strengthen the research focus of the Department of Psychology by setting up their own research group and who will actively participate in collaborations and research initiatives at the Department of Psychology and the Philipps University. The professorship will develop computational methods for modeling and evaluating human behavior, efficient information processing, adaptation to the environment and interaction with the environment. The professorship builds a bridge to computer science and thus supports the AI-initiative of the Philipps University of Marburg.

The Faculty of Psychology and Educational Sciences of the University of Coimbra (FPCE-UC) Portugal invites applications from rising and aspiring leaders in Cognitive Science and Neuroscience for 2 tenure-track positions at the Assistant (1) and Associate (1) Professor level. These positions are part of a transformative ERA Chair grant CogBooster from the European Union to FPCE-UC led by Dr. Alfonso Caramazza. The goal of CogBooster is to implement a strong and international line of research in Cognitive Science/Neuroscience, so as to contribute to the ongoing renewal of the Psychological and Brain Sciences in Portugal over the next decade.

The AI Department of the Donders Centre for Cognition (DCC), embedded in the Donders Institute for Brain, Cognition and Behaviour, and the School of Artificial Intelligence at Radboud University Nijmegen are looking for a researcher in reinforcement learning with an emphasis on safety and robustness, an interest in natural computing as well as in applications in neurotechnology and other domains such as robotics, healthcare and/or sustainability. You will be expected to perform top-quality research in (deep) reinforcement learning, actively contribute to the DBI2 consortium, interact and collaborate with other researchers and specialists in academia and/or industry, and be an inspiring member of our staff with excellent communication skills. You are also expected to engage with students through teaching and master projects not exceeding 20% of your time.

Join our AI research group at the Institute of Digital Games - University of Malta. We have a number of research posts (research associates, PhD students and Postdoctoral fellows) open currently. Be part of a research team that builds the next generation AI algorithms that play, feel and design games. We are looking for excellent candidates with a good grasp of as many of the following areas as possible: deep/shallow learning, affect annotation and modelling, human-computer interaction, computer vision, behaviour cloning, procedural content generation, generative systems.

We have two fully funded PhD scholarships in data science, with an emphasis on neural network applications/research, available at our Institute for Analytics and Data Science.

The Cyprus Institute invites applications for a Post-Doctoral Fellow to pursue research in Machine Learning. The successful candidate will be actively engaged in cutting-edge research in terms of core problems in ML and AI such as developing efficient and interpretable deep nets, continual learning, neuro-inspired ML, self-supervised learning, and other cutting-edge topics. The candidate should have deep understanding of machine learning fundamentals (e.g., linear algebra, probability theory, optimization) as well as broad knowledge of the state-of-the-art in AI and machine and learning. Additionally, the candidate should have extensive experience with ML programming frameworks (e.g., PyTorch). The candidate will be working primarily with two PIs: Prof. Constantine Dovrolis and Prof. Mihalis Nicolaou. The appointment is for a period of 2 years, with the option of renewal subject to performance and the availability of funds.

ENSTA, IP Paris is looking to hire a talented master student in machine learning on a collaborative project with Ecole Polytechnique. The intern will be part of the laboratory U2IS of ENSTA Paris and will collaborate with LIX, Ecole Polytechnique. The internship’s goal is to explore how active imitation can improve the algorithm GARA. The intuition in this context is that human demonstrations can be used to determine the structure of the task (ie. which subtasks need to be achieved) as well as determining a planning strategy to solve it (ie. the order of achieving subtasks). During this internship we will: Study the relevant state-of-art and make a research hypothesis about the usefulness of introducing human demonstrations into the considered HRL algorithm, Design and implement a component to learn from human demonstrations in GARA, Conduct an experimental evaluation to assess the research hypothesis. The intern is expected to also collaborate with a PhD student whose work is closely related to this topic.

Fordham University (New York City) has developed a unique Ph.D. program in Computer Science, tuned to the latest demands and opportunities of the field. Upon completion of the Ph.D. in Computer Science program, students will be able to demonstrate the fundamental, analytical, and computational knowledge and methodology needed to conduct original research and practical experiments in the foundations and theory of computer science, in software and systems, and in informatics and data analytics. They will also be able to apply computing and informatics methods and techniques to understand, analyze, and solve a variety of significant, real-world problems and issues in the cyber, physical, and social domains. Furthermore, they will be able to conduct original, high-quality, ethically informed, scientific research and publish in respected, peer-reviewed, journals and conferences. Lastly, they will be able to effectively instruct others in a variety of topics in Computer Science at the university level, addressing ethics, justice, diversity, and sustainability. This training and education means that graduates can pursue careers at the university level, but also research and leadership positions in industry and government and within the leading technology companies. A hallmark of the program is early involvement in research, within the first two years of the program. Students will have the opportunity to carry out research in machine learning and AI/robotics, big data analytics and informatics, data and information fusion, information and cyber security, and software engineering and systems.

The position involves conducting research in computational neuroscience and bio-inspired machine intelligence, writing research articles and presenting them at international conferences, publishing in neuroscience journals and machine learning venues such as ICML, NeurIPS, ICLR, etc., and interacting and collaborating with experimental neuroscience groups or neuromorphic hardware developers nationally and internationally.

The Department of Computer Science at University of Miami is inviting applications for tenure-track or tenure eligible faculty positions at levels of Associate Professor and Professor. The successful candidates must conduct research in Data Science, including areas such as Machine Learning, Deep Learning, Computer Vision, Cognitive Cybersecurity, Blockchain, Real-time Analytics, Streaming Analytics, Cyber-analytics, and Edge Computing, and are expected to develop/maintain an internationally recognized research program. The selected candidate will be expected to teach classes at the undergraduate and graduate levels. The faculty in these positions will be housed primarily in the Department of Computer Science and will have responsibilities in the Institute for Data Science and Computing (IDSC).

Open professorship in Industrial AI with a focus on Neurosymbolic Learning & Reasoning. The role involves shaping research and teaching in the field of neurosymbolic approaches for industrial applications internationally and forming our environment in a lasting way.

Our Deep NeuroCognition Lab in NTU and A*STAR, Singapore is currently recruiting multiple PhD students and postdocs. Research experiences in neuroscience, cognitive science, and AI are preferred. Students and staff members will receive competitive monthly salaries/scholarships and other benefits (e.g. medical insurance, annual leave, sick leave).

The Max Planck Institute for Intelligent Systems and the Universities of Stuttgart and Tübingen collaborate to offer an interdisciplinary doctoral program, the International Max Planck Research School for Intelligent Systems (IMPRS-IS). This doctoral program will accept its ninth generation of Ph.D. students in spring of 2024. This school is a key element of Baden-Württemberg’s Cyber Valley initiative to accelerate basic research and commercial development in artificial intelligence and robotics. We seek students who want to earn a doctorate while contributing to world-leading research in areas such as Artificial Intelligence, Biomedical Technology, Computational Cognitive Science, Computer Vision and Graphics, Control Systems and Optimization, Data Science & Visualization, Haptics and Human-Computer Interaction, Machine Learning, Micro- and Nano-Robotics, Natural Language Processing, Neuroscience, Perceptual Inference, Robotics and Human-Robot Interaction, Soft Robotics and Materials. Admitted students can join our program starting in spring of 2025. You will be mentored by our internationally renowned faculty. You will register as a university doctoral student and conduct research. IMPRS-IS offers a wide variety of scientific seminars, workshops, and social activities. All aspects of our program are in English. Your doctoral degree will be conferred when you successfully complete your doctoral project. Our dedicated staff members will assist you throughout your time as a doctoral student.

Applications are invited for an academic position in machine learning in the School of Informatics at the University of Edinburgh, as part of a continuing expansion in Machine Learning and Artificial Intelligence. The appointment will be full-time and open-ended. The successful candidate will have (or be near to completing) a PhD, an established research agenda and the enthusiasm and ability to undertake original research, and to lead a research group. They will show excellent teaching capability and engagement with academic supervision. We are seeking current and future leaders in the field. We seek candidates with research interests in the development of cutting-edge machine learning methods. Candidates will have a research interests in principled approaches to machine learning, machine learning for novel or critical applications, and/or the development of novel methods of wide applicability and with state-of-the-art capability.

The KINDI Center for Computing Research at the College of Engineering in Qatar University is seeking high-caliber candidates for a research faculty position at the level of assistant professor in the area of artificial intelligence (AI). The applicant should possess a Ph.D. degree in Computer Science or Computer Engineering or related fields from an internationally recognized university and should demonstrate an outstanding research record in AI and related subareas (e.g., machine/deep learning (ML/DL), computer vision, robotics, natural language processing, etc.) and fields (e.g., data science, big data analytics, etc.). Candidates with good hands-on experience are preferred. The position is available immediately.

Head of a new research group and member of the Centre Board for a Senior Lecturer Autonomous Learning Systems and Reinforcement Learning (incl. responsibility in research & leadership) 50 - 100 %.

Optical imaging is a major research tool in the basic sciences, and is the only imaging modality that routinely enables non-ionized imaging with subcellular spatial resolutions and high imaging speeds. In biological imaging applications, however, optical imaging is limited by tissue scattering to short imaging depths. This prevents large-scale bio-imaging by allowing visualization of only the outer superficial layers of an organism, or specific components isolated from within the organism and prepared in-vitro.

Research articles and laboratory protocol organization often lack detailed instructions for replicating experiments. protocols.io is an open-access platform where researchers collaboratively create dynamic, interactive, step-by-step protocols that can be executed on mobile devices or the web. Researchers can easily and efficiently share protocols with colleagues, collaborators, the scientific community, or make them public. Real-time communication and interaction keep protocols up to date. Public protocols receive a DOI and enable open communication with authors and researchers to foster efficient experimentation and reproducibility.

Research articles and laboratory protocol organization often lack detailed instructions for replicating experiments. protocols.io is an open-access platform where researchers collaboratively create dynamic, interactive, step-by-step protocols that can be executed on mobile devices or the web. Researchers can easily and efficiently share protocols with colleagues, collaborators, the scientific community, or make them public. Real-time communication and interaction keep protocols up to date. Public protocols receive a DOI and enable open communication with authors and researchers to foster efficient experimentation and reproducibility.

The focus of this talk is not about my research in AI or Robotics but my own journey on trying to do research and understand intelligence in a rapidly evolving research landscape. I will trace my path from conducting early-stage research during graduate school, to working on practical solutions within a startup environment, and finally to my current role where I participate in more structured research at a major tech company. Through these varied experiences, I will provide different perspectives on research and talk about how my core beliefs on intelligence have changed and sometimes even been compromised. There are no lessons to be learned from my stories, but hopefully they will be entertaining.

Synthetic face datasets are increasingly used to overcome the limitations of real-world biometric data, including privacy concerns, demographic imbalance, and high collection costs. However, many existing methods lack fine-grained control over identity attributes and fail to produce paired, identity-consistent images under structured capture conditions. In this talk, I will present FLUXSynID, a framework for generating high-resolution synthetic face datasets with user-defined identity attribute distributions and paired document-style and trusted live capture images. The dataset generated using FLUXSynID shows improved alignment with real-world identity distributions and greater diversity compared to prior work. I will also discuss how FLUXSynID’s dataset and generation tools can support research in face recognition and morphing attack detection (MAD), enhancing model robustness in both academic and practical applications.

n the neurosciences the need for some 'overarching' theory is sometimes expressed, but it is not always obvious what is meant by this. One can perhaps agree that in modern science observation and experimentation is normally complemented by 'theory', i.e. the development of theoretical concepts that help guiding and evaluating experiments and measurements. A deeper discussion of 'brain theory' will require the clarification of some further distictions, in particular: theory vs. model and brain research (and its theory) vs. neuroscience. Other questions are: Does a theory require mathematics? Or even differential equations? Today it is often taken for granted that the whole universe including everything in it, for example humans, animals, and plants, can be adequately treated by physics and therefore theoretical physics is the overarching theory. Even if this is the case, it has turned out that in some particular parts of physics (the historical example is thermodynamics) it may be useful to simplify the theory by introducing additional theoretical concepts that can in principle be 'reduced' to more complex descriptions on the 'microscopic' level of basic physical particals and forces. In this sense, brain theory may be regarded as part of theoretical neuroscience, which is inside biophysics and therefore inside physics, or theoretical physics. Still, in neuroscience and brain research, additional concepts are typically used to describe results and help guiding experimentation that are 'outside' physics, beginning with neurons and synapses, names of brain parts and areas, up to concepts like 'learning', 'motivation', 'attention'. Certainly, we do not yet have one theory that includes all these concepts. So 'brain theory' is still in a 'pre-newtonian' state. However, it may still be useful to understand in general the relations between a larger theory and its 'parts', or between microscopic and macroscopic theories, or between theories at different 'levels' of description. This is what I plan to do.

We developed a novel paradigm measuring implicit identity recognition using Fast Periodic Visual Stimulation (FPVS) with EEG among 16 students and 12 police officers with normal face processing abilities. Participants' neural responses to a 1-Hz tagged oddball identity embedded within a 6-Hz image stream revealed implicit recognition with high-quality mugshots but not CCTV-like images, suggesting optimal resolution requirements. Our findings extend previous research by demonstrating that even unfamiliar identities can elicit robust neural recognition signatures through brief, repeated passive exposure. This approach offers potential for objective validation of face processing abilities in forensic applications, including assessment of facial examiners, Super-Recognisers, and eyewitnesses, potentially overcoming limitations of traditional behavioral assessment methods.

What’s the point of having scientific and technological innovations when only a few can benefit from them? How can we make science more inclusive? Those questions are always in the back of my mind when we perform research in our laboratory, and we have a strong focus on the scientific accessibility of our developed methods from microfabrication to sensor development.

Astrocytes release glutamate by regulated exocytosis in health and disease Vladimir Parpura, International Translational Neuroscience Research Institute, Zhejiang Chinese Medical University, Hangzhou, P.R. China Parpura will present you with the evidence that astrocytes, a subtype of glial cells in the brain, can exocytotically release the neurotransmitter glutamate and how this release is regulated. Spatiotemporal characteristic of vesicular fusion that underlie glutamate release in astrocytes will be discussed. He will also present data on a translational project in which this release pathway can be targeted for the treatment of glioblastoma, the deadliest brain cancer.

High-quality glass lenses are commonplace in the design of optical instrumentation used across the biosciences. However, research-grade glass lenses are often costly, delicate and, depending on the prescription, can involve intricate and lengthy manufacturing - even more so in bioimaging applications. This seminar will outline 3D printing as a viable low-cost alternative for the manufacture of high-performance optical elements, where I will also discuss the creation of the world’s first fully 3D printed microscope and other implementations of 3D printed lenses. Our 3D printed lenses were generated using consumer-grade 3D printers and pose a 225x materials cost-saving compared to glass optics. Moreover, they can be produced in any lab or home environment and offer great potential for education and outreach. Following performance validation, our 3D printed optics were implemented in the production of a fully 3D printed microscope and demonstrated in histological imaging applications. We also applied low-cost fabrication methods to exotic lens geometries to enhance resolution and contrast across spatial scales and reveal new biological structures. Across these applications, our findings showed that 3D printed lenses are a viable substitute for commercial glass lenses, with the advantage of being relatively low-cost, accessible, and suitable for use in optical instruments. Combining 3D printed lenses with open-source 3D printed microscope chassis designs opens the doors for low-cost applications for rapid prototyping, low-resource field diagnostics, and the creation of cheap educational tools.

Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala. This study by Marios Abatis et al. demonstrates how fear conditioning strengthens synaptic connections between engram cells in the lateral amygdala, revealed through optogenetic identification of neuronal ensembles and electrophysiological measurements. The work provides crucial insights into memory formation mechanisms at the synaptic level, with implications for understanding anxiety disorders and developing targeted interventions. Presented by Dr. Kenneth Hayworth, this journal club will explore the paper's methodology linking engram cell reactivation with synaptic plasticity measurements, and discuss implications for memory decoding research.

Facial expressions are inherently dynamic, and our visual system is sensitive to subtle changes in their temporal sequence. However, researchers often use dynamic morphs of photographs—simplified, linear representations of motion—to study the neural correlates of dynamic face perception. To explore the brain's sensitivity to natural facial motion, we constructed a novel dynamic face database using generative neural networks, trained on a verified set of video-recorded emotional expressions. The resulting deepfakes, consciously indistinguishable from videos, enabled us to separate biological motion from photorealistic form. Results showed that conventional dynamic morphs elicit distinct responses in the brain compared to videos and photos, suggesting they violate expectations (n400) and have reduced social salience (late positive potential). This suggests that dynamic morphs misrepresent facial dynamism, resulting in misleading insights about the neural and behavioural correlates of face perception. Deepfakes and videos elicited largely similar neural responses, suggesting they could be used as a proxy for real faces in vision research, where video recordings cannot be experimentally manipulated. And yet, despite being consciously undetectable as fake, deepfakes elicited an expectation violation response in the brain. This points to a neural sensitivity to naturalistic facial motion, beyond conscious awareness. Despite some differences in neural responses, the realism and manipulability of deepfakes make them a valuable asset for research where videos are unfeasible. Using these stimuli, we proposed a novel marker for the conscious perception of naturalistic facial motion – Frontal delta activity – which was elevated for videos and deepfakes, but not for photos or dynamic morphs.

Overview of neurosurgery specialty interplay between neurology, psychiatry and neurosurgery. Discussion on benefits and disadvantages of classifications. Presentation of sub-specialties: trauma, oncology, functional, pediatric, vascular and spine. How does an ordinary day of a neurosurgeon look like; outpatient clinic, emergencies, pre/intra/post operative patient care. An ordinary operation. Myth-busting and practical insights of every day practice. An ordinary operation. Hint for research on clinical problems to be solved. The coming ethical frontiers of neuroprosthetics. In part two we will explore the explanatory gap and its significance. We will review the more than 200 theories of the hard problem of consciousness, from the prevailing to the unconventional. Finally, we are going to reflect on the AI advancements and the claims of LLMs becoming conscious

Join us for the Memory Decoding Journal Club, a collaboration between the Carboncopies Foundation and BPF Aspirational Neuroscience. This month, we're diving into a groundbreaking paper: 'Reconstructing a new hippocampal engram for systems reconsolidation and remote memory updating' by Bo Lei, Bilin Kang, Yuejun Hao, Haoyu Yang, Zihan Zhong, Zihan Zhai, and Yi Zhong from Tsinghua University, Beijing Academy of Artificial Intelligence, IDG/McGovern Institute of Brain Research, and Peking Union Medical College. Dr. Randal Koene will guide us through an engaging discussion on these exciting findings and their implications for neuroscience and memory research.

Unlike traditional monoamine-based antidepressants that require weeks to exert effects, ketamine alleviates depression within hours, though its clinical use is limited by side effects. While ketamine was initially thought to work primarily through NMDA receptor (NMDAR) inhibition, our research reveals a more complex mechanism. We demonstrate that NMDAR inhibition alone cannot explain ketamine's sustained antidepressant effects, as other NMDAR antagonists like MK-801 lack similar efficacy. Instead, the (2R,6R)-hydroxynorketamine (HNK) metabolite appears critical, exhibiting antidepressant effects without ketamine's side effects. Paradoxically, our findings suggest an inverted U-shaped dose-response relationship where excessive NMDAR inhibition may actually impede antidepressant efficacy, while some level of NMDAR activation is necessary. The antidepressant actions of ketamine and (2R,6R)-HNK require AMPA receptor activation, leading to synaptic potentiation and upregulation of AMPA receptor subunits GluA1 and GluA2. Furthermore, NMDAR subunit GluN2A appears necessary and possibly sufficient for these effects. This research establishes NMDAR-GluN2A activation as a common downstream effector for rapid-acting antidepressants, regardless of their initial targets, offering promising directions for developing next-generation antidepressants with improved efficacy and reduced side effects.

The COSYNE 2025 conference was held in Montreal with post-conference workshops in Mont-Tremblant, continuing to provide a premier forum for computational and systems neuroscience. Attendees exchanged cutting-edge research in a single-track main meeting and in-depth specialized workshops, reflecting Cosyne’s mission to understand how neural systems function:contentReference[oaicite:6]{index=6}:contentReference[oaicite:7]{index=7}.

Neurotrophins (NGF, BDNF, NT-3) are endogenous growth factors that exert neuroprotective effects by preventing neuronal death and promoting neurogenesis. They act by binding to their respective high-affinity, pro-survival receptors TrkA, TrkB or TrkC, as well as to p75NTR death receptor. While these molecules have been shown to significantly slow or prevent neurodegeneration, their reduced bioavailability and inability to penetrate the blood-brain-barrier limit their use as potential therapeutics. To bypass these limitations, our research team has developed and patented small-sized, lipophilic compounds which selectively resemble neurotrophins’ effects, presenting preferable pharmacological properties and promoting neuroprotection and repair against neurodegeneration. In addition, the combination of these molecules with 3D cultured human neuronal cells, and their targeted delivery in the brain ventricles through soft robotic systems, could offer novel therapeutic approaches against neurodegenerative diseases and brain trauma.

Do You Know Your Blood Glucose Level? You Probably Should! A single measurement is not enough to truly understand your metabolic health. Blood glucose levels fluctuate dynamically, and meaningful insights require continuous monitoring over time. But glucose is just one example. Many other molecular concentrations in the body are not static. Their variations are influenced by individual physiology and overall health. PhenoSign, a Swiss MedTech startup, is on a mission to become the leader in real-time molecular analysis of complex fluids, supporting clinical decision-making and life sciences applications. By providing real-time, in-situ molecular insights, we aim to advance medicine and transform life sciences research. This talk will provide an overview of PhenoSign’s journey since its inception in 2022—our achievements, challenges, and the strategic roadmap we are executing to shape the future of real-time molecular diagnostics.

About 30% of children with cerebral palsy have congenital hemiplegia, resulting from periventricular white matter injury, which impairs the use of one hand and disrupts bimanual co-ordination. Congenital hemiplegia has a profound effect on each child's life and, thus, is of great importance to the public health. Changes in brain organization (neuroplasticity) often occur following periventricular white matter injury. These changes vary widely depending on the timing, location, and extent of the injury, as well as the functional system involved. Currently, we have limited knowledge of neuroplasticity in children with congenital hemiplegia. As a result, we provide rehabilitation treatment to these children almost blindly based exclusively on behavioral data. In this talk, I will present recent research evidence of my team on understanding neuroplasticity in children with congenital hemiplegia by using a multimodal neuroimaging approach that combines data from structural and functional neuroimaging methods. I will further present preliminary data regarding functional improvements of upper extremities motor and sensory functions as a result of rehabilitation with a robotic system that involves active participation of the child in a video-game setup. Our research is essential for the development of novel or improved neurological rehabilitation strategies for children with congenital hemiplegia.

Digital Minds: Brain Development in the Age of Technology examines how our increasingly connected world shapes mental and cognitive health. From screen time and social media to virtual interactions, this seminar delves into the latest research on how technology influences brain development, relationships, and emotional well-being. Join us to explore strategies for harnessing technology's benefits while mitigating its potential challenges, empowering you to thrive in a digital age.

The centre of memory is the medial temporal lobe (MTL) and especially the hippocampus. In our research, a more flexible brain-inspired computational microcircuit of the CA1 region of the mammalian hippocampus was upgraded and used to examine how information retrieval could be affected under different conditions. Six models (1-6) were created by modulating different excitatory and inhibitory pathways. The results showed that the increase in the strength of the feedforward excitation was the most effective way to recall memories. In other words, that allows the system to access stored memories more accurately.

Decades of research on understanding the mechanisms of attentional selection have focused on identifying the units (representations) on which attention operates in order to guide prioritized sensory processing. These attentional units fit neatly to accommodate our understanding of how attention is allocated in a top-down, bottom-up, or historical fashion. In this talk, I will focus on attentional phenomena that are not easily accommodated within current theories of attentional selection – the “attentional platypuses,” as they allude to an observation that within biological taxonomies the platypus does not fit into either mammal or bird categories. Similarly, attentional phenomena that do not fit neatly within current attentional models suggest that current models need to be revised. I list a few instances of the ‘attentional platypuses” and then offer a new approach, the Dynamically Weighted Prioritization, stipulating that multiple factors impinge onto the attentional priority map, each with a corresponding weight. The interaction between factors and their corresponding weights determines the current state of the priority map which subsequently constrains/guides attention allocation. I propose that this new approach should be considered as a supplement to existing models of attention, especially those that emphasize categorical organizations.

When meta-research (research on research) makes an observation or points out a problem (such as a flaw in methodology), the project should be repeated later to determine whether the problem remains. For this we need meta-research that is reproducible and updatable, or living meta-research. In this talk, we introduce the concept of living meta-research, examine prequels to this idea, and point towards standards and technologies that could assist researchers in doing living meta-research. We introduce technologies like natural language processing, which can help with automation of meta-research, which in turn will make the research easier to reproduce/update. Further, we showcase our open-source litmining ecosystem, which includes pubget (for downloading full-text journal articles), labelbuddy (for manually extracting information), and pubextract (for automatically extracting information). With these tools, you can simplify the tedious data collection and information extraction steps in meta-research, and then focus on analyzing the text. We will then describe some living meta-research projects to illustrate the use of these tools. For example, we’ll show how we used GPT along with our tools to extract information about study participants. Essentially, this talk will introduce you to the concept of meta-research, some tools for doing meta-research, and some examples. Particularly, we want you to take away the fact that there are many interesting open questions in meta-research, and you can easily learn the tools to answer them. Check out our tools at https://litmining.github.io/

In our rapidly evolving digital world, there is increasing concern about the impact of digital technologies and social media on the mental health of young people. Policymakers and the public are nervous. Psychologists are facing mounting pressures to deliver evidence that can inform policies and practices to safeguard both young people and society at large. However, research progress is slow while technological change is accelerating.My talk will reflect on this, both as a question of psychological science and metascience. Digital companies have designed highly popular environments that differ in important ways from traditional offline spaces. By revisiting the foundations of psychology (e.g. development and cognition) and considering digital changes' impact on theories and findings, we gain deeper insights into questions such as the following. (1) How do digital environments exacerbate developmental vulnerabilities that predispose young people to mental health conditions? (2) How do digital designs interact with cognitive and learning processes, formalised through computational approaches such as reinforcement learning or Bayesian modelling?However, we also need to face deeper questions about what it means to do science about new technologies and the challenge of keeping pace with technological advancements. Therefore, I discuss the concept of ‘fast science’, where, during crises, scientists might lower their standards of evidence to come to conclusions quicker. Might psychologists want to take this approach in the face of technological change and looming concerns? The talk concludes with a discussion of such strategies for 21st-century psychology research in the era of digitalization.

Raman spectroscopy is a powerful technique for identifying chemical species by probing their vibrational energy levels, offering exceptional specificity with a relatively simple setup involving a laser source, spectrometer, and microscope/probe. However, the high cost of Raman systems lacking modularity often limits exploratory research hindering broader adoption. To address the need for an affordable, modular microscopy platform for multimodal imaging, we present a customizable confocal Raman spectroscopy setup alongside an open-source acquisition software, ORM (Open Raman Microscopy) Controller, developed in Python. This solution bridges the gap between expensive commercial systems and complex, custom-built setups used by specialist research groups. In this presentation, we will cover the components of the setup, the design rationale, assembly methods, limitations, and its modular potential for expanding functionality. Additionally, we will demonstrate ORM’s capabilities for instrument control, 2D and 3D Raman mapping, region-of-interest selection, and its adaptability to various instrument configurations. We will conclude by showcasing practical applications of this setup across different research fields.

This webinar features presentations from SueYeon Chung (New York University) and Srinivas Turaga (HHMI Janelia Research Campus) on theoretical and computational approaches to sensory cognition. Chung introduced a “neural manifold” framework to capture how high-dimensional neural activity is structured into meaningful manifolds reflecting object representations. She demonstrated that manifold geometry—shaped by radius, dimensionality, and correlations—directly governs a population’s capacity for classifying or separating stimuli under nuisance variations. Applying these ideas as a data analysis tool, she showed how measuring object-manifold geometry can explain transformations along the ventral visual stream and suggested that manifold principles also yield better self-supervised neural network models resembling mammalian visual cortex. Turaga described simulating the entire fruit fly visual pathway using its connectome, modeling 64 key cell types in the optic lobe. His team’s systematic approach—combining sparse connectivity from electron microscopy with simple dynamical parameters—recapitulated known motion-selective responses and produced novel testable predictions. Together, these studies underscore the power of combining connectomic detail, task objectives, and geometric theories to unravel neural computations bridging from stimuli to cognitive functions.

Recent research on the neural crest has revealed the multipotency and plasticity of nerve-associated Schwann cell precursors, which can differentiate into diverse cell types, including parasympathetic neurons, neuroendocrine cells, and mesenchymal stem cells. These findings challenge the traditional view of peripheral nerves, highlighting their role as niches for migratory progenitor cells that contribute to tissue formation and regeneration.

Humans and other animals approach reward and avoid punishment and pay attention to cues predicting these events. Such motivated behavior thus appears to be guided by value, which directs behavior towards or away from positively or negatively valenced outcomes. Moreover, it is facilitated by (top-down) salience, which enhances attention to behaviorally relevant learned cues predicting the occurrence of valenced outcomes. Using human neuroimaging, we recently separated value (ventral striatum, posterior ventromedial prefrontal cortex) from salience (anterior ventromedial cortex, occipital cortex) in the domain of liquid reward and punishment. Moreover, we investigated potential drivers of learned salience: the probability and uncertainty with which valenced and non-valenced outcomes occur. We find that the brain dissociates valenced from non-valenced probability and uncertainty, which indicates that reinforcement matters for the brain, in addition to information provided by probability and uncertainty alone, regardless of valence. Finally, we assessed learning signals (unsigned prediction errors) that may underpin the acquisition of salience. Particularly the insula appears to be central for this function, encoding a subjective salience prediction error, similarly at the time of positively and negatively valenced outcomes. However, it appears to employ domain-specific time constants, leading to stronger salience signals in the aversive than the appetitive domain at the time of cues. These findings explain why previous research associated the insula with both valence-independent salience processing and with preferential encoding of the aversive domain. More generally, the distinction of value and salience appears to provide a useful framework for capturing the neural basis of motivated behavior.

There are over 30 million people with drug-resistant epilepsy worldwide. When neuroimaging and non-invasive neural recordings fail to localise seizure onset zones (SOZ), intracranial recordings become the best chance for localisation and seizure-freedom in those patients. However, intracranial neural activities remain hard to visually discriminate across recording channels, which limits the success of intracranial visual investigations. In this presentation, I present methods which quantify intracranial neural time series and combine them with explainable machine learning algorithms to localise the SOZ in the epileptic brain. I present the potentials and limitations of our methods in the localisation of SOZ in epilepsy providing insights for future research in this area.

Electroencephalography (EEG) has been thoroughly studied for decades in psychiatry research. Yet its integration into clinical practice as a diagnostic/prognostic tool remains unachieved. We hypothesize that a key reason is the underlying patient's heterogeneity, overlooked in psychiatric EEG research relying on a case-control approach. We combine HD-EEG with normative modeling to quantify this heterogeneity using two well-established and extensively investigated EEG characteristics -spectral power and functional connectivity- across a cohort of 1674 patients with attention-deficit/hyperactivity disorder, autism spectrum disorder, learning disorder, or anxiety, and 560 matched controls. Normative models showed that deviations from population norms among patients were highly heterogeneous and frequency-dependent. Deviation spatial overlap across patients did not exceed 40% and 24% for spectral and connectivity, respectively. Considering individual deviations in patients has significantly enhanced comparative analysis, and the identification of patient-specific markers has demonstrated a correlation with clinical assessments, representing a crucial step towards attaining precision psychiatry through EEG.

Cells and microorganisms are motile, yet the stationary nature of conventional microscopes impedes comprehensive, long-term behavioral and biomechanical analysis. The limitations are twofold: a narrow focus permits high-resolution imaging but sacrifices the broader context of organism behavior, while a wider focus compromises microscopic detail. This trade-off is especially problematic when investigating rapidly motile ciliates, which often have to be confined to small volumes between coverslips affecting their natural behavior. To address this challenge, we introduce Trackoscope, an 2-axis autonomous tracking microscope designed to follow swimming organisms ranging from 10μm to 2mm across a 325 square centimeter area for extended durations—ranging from hours to days—at high resolution. Utilizing Trackoscope, we captured a diverse array of behaviors, from the air-water swimming locomotion of Amoeba to bacterial hunting dynamics in Actinosphaerium, walking gait in Tardigrada, and binary fission in motile Blepharisma. Trackoscope is a cost-effective solution well-suited for diverse settings, from high school labs to resource-constrained research environments. Its capability to capture diverse behaviors in larger, more realistic ecosystems extends our understanding of the physics of living systems. The low-cost, open architecture democratizes scientific discovery, offering a dynamic window into the lives of previously inaccessible small aquatic organisms.

Britta Engelhard’s research is devoted to understanding thefunction of the different brain barriers in regulating CNS immunesurveillance and how their impaired function contributes toneuroinflammatory diseases such as Multiple Sclerosis (MS) orAlzheimer’s disease (AD). Her laboratory combines expertise invascular biology, neuroimmunology and live cell imaging and hasdeveloped sophisticated in vitro and in vivo approaches to studyimmune cell interactions with the brain barriers in health andneuroinflammation.

Recent research has seen many behavioral comparisons between humans and deep neural networks (DNNs) in the domain of image classification. Often, comparison studies focus on the end-result of the learning process by measuring and comparing the similarities in the representations of object categories once they have been formed. However, the process of how these representations emerge—that is, the behavioral changes and intermediate stages observed during the acquisition—is less often directly and empirically compared. In this talk, I'm going to report a detailed investigation of the learning dynamics in human observers and various classic and state-of-the-art DNNs. We develop a constrained supervised learning environment to align learning-relevant conditions such as starting point, input modality, available input data and the feedback provided. Across the whole learning process we evaluate and compare how well learned representations can be generalized to previously unseen test data. Comparisons across the entire learning process indicate that DNNs demonstrate a level of data efficiency comparable to human learners, challenging some prevailing assumptions in the field. However, our results also reveal representational differences: while DNNs' learning is characterized by a pronounced generalisation lag, humans appear to immediately acquire generalizable representations without a preliminary phase of learning training set-specific information that is only later transferred to novel data.

2024 BACN Mid-Career Prize Lecture Adaptive behavior requires the ability to focus on a current task and protect it from distraction (cognitive stability), and to rapidly switch tasks when circumstances change (cognitive flexibility). How people control task focus and switch-readiness has therefore been the target of burgeoning research literatures. Here, I review and integrate these literatures to derive a cognitive architecture and functional rules underlying the regulation of stability and flexibility. I propose that task focus and switch-readiness are supported by independent mechanisms whose strategic regulation is nevertheless governed by shared principles: both stability and flexibility are matched to anticipated challenges via an incremental, online learner that nudges control up or down based on the recent history of task demands (a recency heuristic), as well as via episodic reinstatement when the current context matches a past experience (a recognition heuristic).

This seminar, hosted by the LIBRE hub project, will provide an in-depth introduction to the Global Open Science Hardware (GOSH) movement. Since its inception, GOSH has been instrumental in advancing open-source hardware within scientific research, fostering a diverse and active community. The seminar will cover the history of GOSH, its current initiatives, and future opportunities, with a particular focus on the contributions and activities of the Latin American branch. This session aims to inform researchers, educators, and policy-makers about the significance and impact of GOSH in promoting accessibility and collaboration in science instrumentation.

Organised by FENS in partnership with the Austrian Neuroscience Association and the Hungarian Neuroscience Society, the FENS Forum 2024 will take place on 25–29 June 2024 in Vienna, Austria:contentReference[oaicite:0]{index=0}. The FENS Forum is Europe’s largest neuroscience congress, covering all areas of neuroscience from basic to translational research:contentReference[oaicite:1]{index=1}.