Exploring the relationship between adipose tissue and Alzheimer's disease pathogenesis
Miriam Bettinetti-Luque, Trujillo-Estrada Laura, Andreo-Lopez Juana, Campos-Moreno Cynthia, Fatuarte-Juli Ivan, Morales-Cabello Mario, Da Cunha Celia, Sanchez-Mejias Elisabeth, LaFerla FranK M., Gutierrez Antonia, Baglietto-Vargas David · FENS Forum 2024
Alzheimer’s disease (AD) is a complex disorder and multiple molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological feature in AD. Likewise, diabetes and obesity, two metabolic illnesses, are risk factors for AD. These two diseases are associated with an expansion of visceral adipose tissue (VAT). Here, we hypothesize that the visceral adipose tissue may serve as a key communicator organ between the brain and peripheral metabolic disorders and affecting both types of disorders.We used histological s