Topic: Activity-dependent structural plasticity

Activity-dependent structural plasticity (ADSP) plays a significant role in the homeostatic regulation of neuronal connectivity and activity in developing neuronal networks. This process involves intricate activity-dependent interaction between neuronal growth and migration, which shapes synaptic connections and results in network architectures with varying levels of clustering and modularity, influenced by the initial conditions. While excitatory interactions are essential for early network formation, the timely maturation of inhibition is also considered essential for stable activity dynamic

Activity-dependent structural plasticity plays a pivotal role in the self-organization of neuronal networks. Emerging activity continuously feeds back into the growth process, regulating connectivity and activity homeostatically towards an optimal functional dynamic range. Transferred into cell culture, neurons follow the same homeostatic principles. They migrate and regrow neurites to establish synaptic connectivity and spontaneous network activity. Despite of homeostatic regulation, the resulting network structure and activity dynamics exhibit considerable variability across and within studi