Topic: activity manifold

The vertebrate telencephalon is the site of complex cognitive processes such as spatial cognition. The larval zebrafish telencephalon is a compact circuit of ~10,000 neurons that nevertheless contains homologous structures to the mammalian basal ganglia and limbic system (e.g. hippocampus and amygdala). However, despite long-standing evidence that spatial navigation and learning in adult fish requires an intact telencephalon, cells believed to underlie spatial cognition in mammals (e.g. place and grid cells) have yet to be established in any fish species. Using a tracking microscope to image b

In ferret visual cortex, spontaneous activity before eye-opening is organised into large-scale, modular patterns in the absence of long-range projections. This correlated activity reveals endogenous networks that predict aspects of future orientation selectivity. Previous modelling works have shown that the long-range correlations observed in these networks can arise from locally connected neurons through multi-synaptic interactions. Here we seek to map the structure of cortical lateral interactions through localised perturbations in vivo.We first constructed a rectified recurrent neural netwo