Topic: adenosine signaling

Olfactory dysfunction is an early symptom of neurodegenerative diseases, including Parkinson’s disease (PD) and multiple sclerosis (MS). Recent data showed that 30-40% MS patients and 90 % PD patients experience olfactory dysfunction. Studies have shown that adenosine signaling has a pivotal role in olfactory processing; thus, deciphering the changes in adenosine signaling may be crucial for understanding the disease pathogenesis. Aim of this study was to characterize olfactory dysfunction from the aspect of adenosine metabolism, focusing on ecto-5’ nucleotidase (CD73) in the olfactory bulb (O

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, leading to reduced striatal dopamine and motor and non-motor symptoms. The imbalance of adenosine signaling plays a role in the pathogenesis of PD, particularly through increased A2AR and reduced A1R activity affecting D2R and D1R signaling pathways, respectively. This imbalance interferes with the reciprocal modulation of adenylate cyclase by A1R/D1R and A2AR/D2R and impairs motor control. Despite existing treatment options, there is an unmet need for new interve