Exposure to food-associated sensory cues during development program central response to food and obesity
Laura Casanueva Reimon, Ayden Gouveia, André Carvalho, Lionel Rigoux, Anna Lena Cremer, Frederik Dethloff, Yvonne Hinze, Paul Klemm, Heiko Backes, Patrick Giavalisco, Sophie M. Steculorum · FENS Forum 2024
Maternal obesity predisposes offspring to metabolic diseases. Insulin resistance and adiposity secondary to maternal calorie-rich high-fat diet consumption are considered key contributors to such developmental programming. Here, we show that non-nutritive sensory components of high-fat diet (HFD), beyond its hypercaloric, obesogenic effects, are sufficient to alter metabolic health in the offspring. To dissociate the caloric and sensory components of HFD, we fed dams a diet isonutritional to a normal chow diet but enriched with fat-related odors mimicking the sensory signature of a commonly us
ePoster · Neuroscience