Topic: Adverse childhood experiences

Aim Adverse childhood experiences (ACEs) are related to worse mental health outcomes and reduced grey matter volume (GMV) in dorsolateral prefrontal cortex (DLPFC), amygdala (AMY), and hippocampus (HC), which has mostly been observed in samples of 12–50-year-old individuals. We hypothesize that these anomalies persist in middle- to old-age and brain structure (ROIs: HC, AMY, DLPFC) mediates the association of ACE with anxiety and depression symptoms. Methods The study uses data from the Hamburg City Health Study, which randomly sampled adults between 45–74 years (N=2,525) and tested them for a

Major Depressive Disorder (MDD) is characterized by a constellation of symptoms, summarized into three major categories: passive coping strategies, anhedonia, and social impairment.The use of animal models can help to explore these symptoms and investigate their underlying mechanisms, such as oxytocinergic and opioids alterations within the mesocorticolimbic circuit.Exposure to Early Life Adversities (ELA), including Attachment Bond Disruption and Adverse Childhood Experiences, such as Neglect, represents one of the most important risk factors for development of MMD.To model attachment disrupt