ePoster · Neuroscience
TPH2 knockout rats cannot accept social defeat in resident-intruder test
Ilya Zhukov, Vsevolod Nemets, Yazen Alnefeesi, Petr Shabanov, Natalia Alenina, Raul Gainetdinov · FENS Forum 2024
Brain serotonin (5-HT) is one of the key regulators of aggressive behavior and social defeat stress mechanisms. We had previously found that abolishing central 5-HT biosynthesis increases aggression, as tryptophan hydroxylase 2 (Tph2-/-) knockout rats (TPH2-KO) are more aggressive than wild-type (WT) counterparts. In this elaboration, we compared different types of intruders to expand our understanding of the aggressive phenotype in TPH2-KO rats. The resident-intruder paradigm was applied to evaluate the territorial aggression of rats, where isolated residents (TPH2-KO, WT male, 36 weeks, n=9)