Topic: allopregnanolone

Alzheimer’s disease (AD) is a progressive age-associated brain disorder in which deficits in episodic memory function are among the first cognitive symptoms observed. Clinical findings indicate that AD patients are more susceptible to anesthesia-induced postoperative cognitive dysfunction, which is in line with the well-known fact that general anesthesia is more detrimental in the two extreme age groups, neonates/infants and the elderly. Alfaxalone (ALX) is the synthetic analog of allopregnanolone. It is currently in use only in veterinary practice as a fast-acting anesthetic with a high thera

Neuroactive steroids such as allopregnanolone that act as a positive allosteric modulator of synaptic and extrasynaptic δ-subunit-containing GABAA receptors, has shown antidepressant effects on depressive symptoms in both clinical and preclinical studies. However, the neuronal dynamics associated with these effects are still unknown. In the present study, we discovered that allopregnanolone, but not the benzodiazepine diazepam, has antidepressant-like effects in the social interaction test (SIT) of social defeat stress (SDS) model mice by decreasing intervals of repetitive social interaction (

Conjugated 3α5β neuroactive steroids, such as allopregnanolone and pregnanolone, have garnered significant interest due to their potential therapeutic effects in various neurological conditions. Previously, the neuroprotective effect of 3α5β pregnanolone glutamate (3α5β-PG) was demonstrated in the model of focal cerebral ischemia in immature rats. The goal of this study was to determine electrophysiological correlates of ischemia-induced seizures and validate effects of 3α5β-PG treatment on seizure’s onset and EEG changes in twelve-day-old (P12) Wistar rats. Focal cerebral ischemia was induced

Background: Alzheimer's disease (AD) is a neurological disease characterised pathologically by loss of synapses and neurones, accumulation of amyloid-beta (Aβ) deposits and formation of neurofibrillary tangles. This results in progressive cognitive impairment as people age. Ganaxolone, a synthetic analogue of allopregnanolone, has shown a protective effect on gliosis associated with demyelination. However, its effect on Aβ deposits and neuronal loss associated with AD is still unknown. Additionally, its effect on liver x receptors (LXR) has not yet been reported. In this study, we investigated