Topic: γ-aminobutyric acid receptors

Dopamine (DA) transmission plays a key role in reward, motivation, and action selection, and becomes dysregulated in substance-use disorders and Parkinson’s disease. Midbrain DA neurons form vast axonal arbours in the striatum, presenting opportunities for local axonal regulation of DA signalling by diverse interacting mechanisms. Striatal DA transporters (DATs) and γ-aminobutyric acid receptors (GABA-Rs) are both thought to limit DA axon activation and thereby attenuate DA release probability whilst also supporting the frequency-dependence of DA release. We tested whether these convergent mec

Maintaining the delicate balance between excitatory and inhibitory synaptic activity is crucial for proper brain function. The endosomal trafficking complex, retromer, plays a pivotal role in synaptic function by regulating the post-endocytic sorting of a variety of integral proteins at both excitatory and inhibitory synapses. As a result, SNX27/retromer is emerging as a potential mediator of excitatory/inhibitory crosstalk. In surface proteomic screens from primary cultured neurons, we have shown that a variety of subunits of γ-aminobutyric acid receptors (GABAARs) exhibit reduced surface exp