Topic: receptors

Traumatic brain injury (TBI) remains the leading cause of death and disability worldwide with no existing effective treatment. The early phase after TBI induction triggers numerous molecular cascades to regulate adaptive processes and cortical network activity. Kinases play a particularly prominent role in modifying peptide substrates, which include ion channels, receptors, transcription factors and inflammatory mediators. This project aimed to better understand the post-injury serine/threonine kinome; 1) Which kinases conduct phosphorylation-induced alterations of target peptides following un