Topic: anterior thalamic nucleus

The head direction (HD) system functions as the brain's compass system. HD signals are generated based on vestibular inputs that provide information on self-movement. They are combined with signals that permit orientation coding with respect to external landmarks. Lesion studies point to the Presubiculum as a strong candidate for the integration of HD and landmark signals, but the underlying cellular mechanisms remain to be clarified. Here we show that the presubiculum receives HD signals from the anterior thalamic nucleus (ATN) and visual landmark information from the retrosplenial cortex (RS

The Head Direction (HD) system is important for spatial orientation. The Anterior thalamic nucleus (ATN) is one of the critical brain regions for the system. It is composed of two main subdivisions: the anterodorsal nucleus (AD) and anteroventral nucleus (AV). It receives HD inputs originated from the lateral mammillary nucleus (LMN), and it sends HD information to the retrosplenial cortex (RSC) and presubiculum (PrS). However, it has been unclear which thalamic neurons target RSC or PrS. Moreover, the input connectivity from the upstream lateral mammillary nucleus (LMN) is has not been clearl