Topic: presubiculum

The head direction (HD) system functions as the brain's compass system. HD signals are generated based on vestibular inputs that provide information on self-movement. They are combined with signals that permit orientation coding with respect to external landmarks. Lesion studies point to the Presubiculum as a strong candidate for the integration of HD and landmark signals, but the underlying cellular mechanisms remain to be clarified. Here we show that the presubiculum receives HD signals from the anterior thalamic nucleus (ATN) and visual landmark information from the retrosplenial cortex (RS

Head-direction (HD) cells function as the brain's neuronal compass. Their activity is based on vestibular signals and controlled by visual landmarks. The integration of multisensory signals during passive rotation and the role of the presubiculum in merging vestibular and visual inputs are yet to be fully understood.We manipulated vestibular and visual cues using a novel paradigm. Head-fixed mice were rotated on a motorized platform in a pseudo-random fashion, covering all angles, while surrounded by a semi-transparent dome displaying visual cues. Using Neuropixel probes, we investigated the a

The head direction (HD) system functions as the brain's compass, forming our inner representation of the external world. Single HD neurons increase their firing rate when the head of an animal is oriented in a specific direction. The HD signal is internally generated, driven by vestibular information and it is anchored to stable visual cues in the environment. How specific brain microcircuits combine the stable maintenance of the HD signal as well as flexibility upon reorientation is unknown. Our goal is to understand the dynamical structure of the head direction neural network in the presubic

The Head Direction (HD) system is important for spatial orientation. The Anterior thalamic nucleus (ATN) is one of the critical brain regions for the system. It is composed of two main subdivisions: the anterodorsal nucleus (AD) and anteroventral nucleus (AV). It receives HD inputs originated from the lateral mammillary nucleus (LMN), and it sends HD information to the retrosplenial cortex (RSC) and presubiculum (PrS). However, it has been unclear which thalamic neurons target RSC or PrS. Moreover, the input connectivity from the upstream lateral mammillary nucleus (LMN) is has not been clearl