Topic: APP/PS1dE9

Disrupted neural oscillations and memory are common features of Alzheimer's disease (AD). Our previous studies have demonstrated the potential to restore theta oscillations by utilizing LFP-guided closed-loop optogenetic stimulation of local parvalbumin-positive (PV+) interneurons in the CA1 region of the hippocampus in APP/PS1dE9 mice. Furthermore, employing the same protocol, we successfully enhanced the performance of transgenic mice in a spatial memory tests. Based on these findings, our objective is to investigate the impact of PV+ stimulation on circuit function within the CA1 region. To

Alzheimer’s disease (AD) is characterized by memory deficits including spatial working memory. The hippocampus (HPC) and the prefrontal cortex (PFC) exhibit a prominent AD pathology and are relevant brain regions for spatial working memory. The HPC and PFC are connected by long-range projections and operate in synergy to consolidate and retrieve memories. Both, excitatory and inhibitory long-range projections between the HPC and the PFC have been poorly characterized under AD-like conditions. In fact, it remains unknown, whether structural and functional connectivity deficits between these bra